超声靶向微泡破坏与载药/载基因纳米粒联合应用的生物物理学机制及应用研究进展

Progress in Biophysical Mechanism and Application of Ultrasound-targeted Microbubble Destruction in Combination with drug-and gene-loaded Nanoparticles

超声靶向微泡破坏(ultrasound-targeted microbubble destruction, UTMD)能够安全、高效、简便地递送药物与基因,是当前超声医学领域的研究热点,其机制主要涉及超声辐照微泡引起的空化效应及其二级效应、内吞作用与声辐射力。近年来,随着生物医学材料科学迅猛发展,纳米载药系统取材更加广泛,制备方法愈发精良,载药量日益提高。将纳米载药系统与UTMD进行联合,可以扬长避短,为肿瘤等多种疾病的治疗带来新的思路与希望。本文旨在对UTMD与载药/载基因纳米粒联合应用的生物物理学机制及应用研究进行综述并提出展望。

Ultrasound-targeted microbubble destruction (UTMD) can deliver drugs and genes safely, efficiently and conveniently, which has already become present research focuses. Its mechanism is mainly related to cavitation effect and its secondary effects, endocytosis and acoustic radiation. In recent years, with the rapid development of biomedical materials science, the nanocarrier drug delivery system has become more extensive, the preparation methods have become more sophisticated, and the drug loading has increased. The combination of nanocarrier drug delivery system and UTMD can help circumvent weaknesses and bring new ideas and hopes for the treatment of tumors and other diseases. The purpose of this paper is to review the biophysical mechanisms and applications of UTMD combined with drug-and gene-loaded nanoparticles and to provide a perspective.