血清25-羟维生素D水平与儿童骨密度的相关性研究

Correlation Study between Serum 25-hydroxyvitamin D Level and Bone Mineral Density in Children

目的:研究血清25-羟维生素D[25-(OH)D]水平与儿童骨密度(BMD)的相关性。方法:选择2017年1月到2017年12月在亳州市人民医院接受健康体检的儿童100例作为研究对象。根据血清25-(OH)D水平对维生素D(Vit D)营养状况进行分组,其中严重缺乏组9例,缺乏组28例,不足组42例和充足组21例。对比不同年龄段和不同性别儿童血清25-(OH)D、BMD水平以及不同Vit D营养状况儿童对应的BMD水平,并采用Spearman相关性分析法分析血清25-(OH)D水平与儿童BMD、年龄的相关性。结果:5-9岁和10-14岁儿童的血清25-(OH)D及BMD水平均分别低于1-4岁儿童,而10-14岁儿童又低于5-9岁儿童(P<0.05)。男童的血清25-(OH)D及BMD水平均分别高于女童,差异有统计学意义(P<0.05)。不足组、缺乏组、严重缺乏组儿童的BMD水平均分别低于充足组,且缺乏组和严重缺乏组低于不足组,严重缺乏组又低于缺乏组(P<0.05)。根据Spearman相关性分析结果显示,血清25-(OH)D水平与儿童BMD呈正相关,而与年龄呈负相关(P<0.05),年龄与儿童BMD呈负相关(P<0.05)。结论:血清25-(OH)D水平与儿童BMD呈正相关,但与年龄则呈负相关,及时补充适量的Vit D以满足儿童的机体所需,有利于儿童健康成长。

Objective: To study the correlation between serum 25-hydroxyvitamin D [25-(OH)D] level and bone mineral density(BMD) in children. Methods: 100 children who were received physical examination in Bozhou People’s Hospital from January 2017 to December 2017 were selected as the research subjects.According to the serum 25-(OH) D level, the nutritional status of vitamin D(Vit D) in children was divide into groups, including severe deficiency group with 9 cases, deficiency group with 28 cases, insufficiency group with 42 cases and sufficient group with 21 cases. The levels of serum 25-(OH)D and BMD in children with different ages and sexes were compared, and the level of BMD in children with different Vit D nutritional status was compared, the correlation between serum 25-(OH)D level and BMD, age of children was analyzed by Spearman correlation analysis. Results: The levels of serum 25-(OH)D and BMD in children aged 5-9 and 10-14 years old were significantly lower than those of children aged 1-4 years old, children aged 10-14 years old was significantly lower than children aged 5-9 years old(P<0.05). The levels of serum 25-(OH)D and BMD in boys were higher than those of girls, and the difference was statistically significant(P<0.05). The level of BMD of children in insufficiency group, deficiency group and severe deficiency were lower than that in sufficient group, respectively, the deficiency group and severe deficiency group was significantly lower than that of insufficiency group, the severe deficiency group was lower than that of the deficiency group(P<0.05). The results of Spearman correlation analysis show that serum 25-(OH)D level was positively correlated with BMD in children, but which was negatively correlated with age(P<0.05), age was negatively correlated with BMD in children(P<0.05). Conclusion: The level of serum25-(OH) D is positively correlated with BMD in children, but it is negatively correlated with age. It is necessary to replenish the right amount of Vit D in time to meet the needs of children’s body, which is beneficial to the healthy growth of children.