辛伐他汀治疗脂肪肝对患者肝功能及睡眠质量的影响

Effects of Simvastatin on Liver Function and Sleep Quality in Patients with Fatty Liver

目的:观察辛伐他汀治疗脂肪肝对患者肝功能及睡眠质量的影响。方法:选取2016年4月至2018年4月福建医科大学孟超肝胆医院肝内科收治的非酒精性脂肪肝患者60例作为研究对象,随机分为观察组和对照组,每组30例。对照组低脂饮食,适当运动,观察组在对照组的基础上服用辛伐他汀治疗。比较2组患者血脂变化、肝功能变化、睡眠质量变化。结果:2组患者治疗初始血脂各项指标之间无统计学意义(P> 0. 05),治疗后观察组患者的TC、LDL-C、TG均显著低于对照组,HDL-C高于对照组(P <0. 05)。2组患者治疗初始肝功能各项指标之间无统计学意义(P> 0. 05),治疗后观察组患者的ALT、AST、γ-GGT、TBi L均显著低于对照组(P <0. 05)。2组患者在治疗前和治疗后PSQI评分均无统计学意义(P> 0. 05)。结论:辛伐他汀能够有效调节血脂,改善脂肪肝患者肝功能的同时不影响患者睡眠质量。

Objective: To observe the effect of simvastatin on liver function and sleep quality in patients with fatty liver. Methods: A Total of 60 patients with non-alcoholic fatty liver admitted to the Department of Hepatology of our hospital from April 2016 to April 2018were studied as the research objects.They were randomly divided into simvastatin group and control group with 30 patients in each group.The control group was fed a low-fat diet and exercised properly.The simvastatin group was treated with simvastatin on the basis of the control group.The changes of blood lipid, liver function and sleep quality were compared between the two groups. Results: There was no difference in the initial blood lipid indexes between the two groups( P >0.05).After treatment, TC, LDL-C and TG in the simvastatin group were significantly lower than those in the control group, and HDL-C was higher than that in the control group( P <0.05).There was no difference in the initial liver function between the two groups( P >0.05).After treatment, the ALT, AST, gamma-GGT and TBiL in simvastatin group were significantly lower than those in control group( P <0.05).There was no significant difference in PSQI scores between the two groups before and after treatment( P >0.05). Conclusion: Simvastatin can effectively regulate blood lipid and improve liver function in patients with fatty liver without affecting sleep quality.