Rh表型在不同疾病患者中的分布特征

The distribution characteristics of Rh phenotypes in patients with different diseases

目的探讨Rh表型在不同疾病患者中的分布特点及其相关性。方法采用免疫血清学方法对2 717例健康人群(对照组)和不同疾病患者(共7 812例)做Rh抗原分型检测,并对其进行统计学分析。结果献血者与肾脏疾病、消化疾病、肿瘤疾病患者的Rh表型分布差异无统计学意义(χ~2值分别为4.630、8.629、8.787,均为P>0.05),与神经疾病、血液疾病患者的Rh表型分布差异有统计学意义(χ~2值分别为14.961、34.168,均为P<0.05);在神经疾病患者中,Rh表型中的DCcEE和DCCEe的相对危险度较高(OR=4.771、2.344),在血液疾病患者中,Rh表型中Dccee和DCcEE的相对危险度较高(OR=3.446、3.014)。结论健康人群的Rh表型分布与神经疾病、血液疾病患者的Rh表型分布规律有一定的差异,Rh表型与某些疾病的发生发展有一定的相关性。

Objective To explore the distribution characteristics and correlation of Rh phenotype in patients with different diseases. Methods A total of 2717 healthy people ( the control group) and the patients with different diseases ( 7 812 cases) were detected by the serum immunological method,and the statistical analysis was made on the Rh typing. Results There was no significant difference in the distribution of Rh phenotype between the donors and the patients with renal diseases, digestive diseases or tumor diseases (χ^2= 4. 630, 8. 629, 8. 787,respectively,P>0. 05);there was a significant difference in the distribution of Rh phenotypes between blood donors and patients with neurologic and hematological diseases (χ^2= 14. 961, 34. 168,respectively,P<0. 05). The relative risk of DCcEE and DCCEe was high in patients with nerve disease ( OR= 4. 771,2. 344);the relative risk of Dccee and DCcEE was high in the patients with blood diseases er ( OR= 3. 446, 3. 014).Conclusion The distribution of Rh phenotype in healthy population is different from that in patients with neurological and hematological diseases.Rh phenotype is related to the occurrence and development of some diseases.