智托洁白丸对低氧应激性胃溃疡的保护作用

Protective Effect of Zhituo Jiebai Pills on Hypoxic Stress Gastric Ulcer

本研究为了探讨智托洁白丸(ZJP)对模拟海拔5 000 m的高原环境所诱发的大鼠低氧应激性胃溃疡的影响,以ZJP的药效与机制作为研究对象,通过组织病理形态学和透射电镜观察、腺苷酸含量和能荷测定、SOD活性和MDA含量测定的方法,发现ZJP由于增加大鼠胃粘膜的ATP、ADP、AMP含量及能荷、增加SOD活性,降低MDA含量而减轻了低氧应激所导致的胃粘膜的溃疡损伤,表明ZJP具有保护低氧应激性胃溃疡的药理作用。我们的研究有助于为高原病的防治提供药学理论依据。

The objective of this study was to explore the effect of Zhituo Jiebai Pills(ZJP)on rats with hypoxic gastric ulcer induced by simulated altitude of 5 000 m.The pharmacodynamics and mechanism of ZJP were focused as objects of this research.By means of histopathologic morphology and ultrastructural changes,content of adenosine and energy charge determination,activity of SOD and content of MDA determination,we found that the ZJP could alleviate gastric mucosal ulcer damage caused by hypoxic stress by increasing ATP,ADP,AMP content and energy charge,increasing SOD activity and reducing MDA content in gastric mucosa of rats,which indicated that ZJP had the pharmacological action of protecting gastric ulcer caused by hypoxic stress.This research would be helpful to provide the pharmacological basis for the prevention and treatment ofaltitude diseases.