小柴胡汤加减联合奥美拉唑对慢性胃炎具有治疗增效作用

Xiaochaihu Decoction Combined with Omeprazole Has Synergic Therapeutic Effect on Chronic Gastritis

本研究选取本院收治的慢性胃炎患者114例并根据治疗方法不同分为对照组和观察组。对照组患者采用奥美拉唑治疗,观察组患者采用奥美拉唑联合小柴胡汤加减治疗,分析小柴胡汤加减联合奥美拉唑对慢性胃炎血清表皮生长因子(EGF)、胃黏膜氧化酶-2 (COX-2)蛋白表达情况的影响及护理对策。研究结果表明,治疗前两组患者胃镜检查充血水肿、糜烂、黏膜白相、颗粒增生发生率比较无统计学差异(p>0.05);治疗后,观察组患者各项指标发生率低于对照组(p<0.05);治疗前,两组患者血清EGF、Bcl-2、CRP和胃黏膜COX-2、P-p65表达水平比较无统计学差异(p>0.05),治疗后发现观察组患者血清EGF水平高于对照组,血清Bcl-2、CRP和胃黏膜COX-2、P-p65表达水平低于对照组(p<0.05);治疗前,两组患者在躯体功能、躯体职能、躯体疼痛、情感职能、心理健康评分等生活质量评分上比较无统计学差异(p<0.05),治疗后,观察组患者各项评分高于对照组(p>0.05)。本研究初步结论说明,小柴胡汤加减联合奥美拉唑治疗慢性胃炎疗效显著,可改善患者血清EGF、Bcl-2和胃黏膜COX-2表达水平,提高患者生活质量。

To analyze the effect of the combination of modified Xiaocaihu decoction and omeprazole on the expression of serum epidermal growth factor(EGFN)and gastric mucosal oxygenase-2(COX-2)protein in patients with chronic gastritis and the nursing countermeasures,114 patients with chronic gastritis in our hospital were selected and divided into two groups:control group and observation group,according to different treating methods.The control group was treated with omeprazole.The patients in observation group were treated with omeprazole combined with Xiaocaihu decoction.It was found in this study that before treatment,there was no significant difference in the incidence of hyperemia,edema,erosion,mucosal white phase and granular hyperplasia between the two groups(p>0.05).After treatment,the items in the patients in the observation group were lower than those of the control group(p<0.05).Before treatment,serum levels of EGF-1,Bcl-2,CRP and the expression level of gastric mucosal COX-2 and P-p65 in both groups had no statistical differences(p>0.05).Aftertreatment,the serum EGF level of the patients in the observation group was higher than that of the control group,and the levels of Bcl-2,CRP,COX-2 and P-p65 in the gastric mucosa were higher in the observation group(p<0.05).Before treatment,there was no significant difference in the scores of life quality,which were physical function,physiological role,physical pain,emotional function,and mental health,between the two groups(p>0.05).After treatment,all the scores in observation group were higher than those in the control group(p<0.05).The preliminary results of this study indicated that modified Xiaochaihu decoction combined with omeprazole was effective in the treatment of chronic gastritis.It could improve the level of serum EGF,Bcl-2 and the expression of gastric mucosal COX-2,and improve the life quality of patients with chronic gastritis.