急性腔隙性脑梗死患者血清miR-19b-3p水平与认知功能相关性研究

Correlation between Serum miR-19b-3p Level with Cognitive Function in Patients with Acute Lacunar Infarction

目的分析急性腔隙性脑梗死患者血清miR-19b-3p水平与认知功能的相关性。方法选择2015年2月—2017年2月收治的急性腔隙性脑梗死96例作为观察组,选取同期健康体检者60例作为对照组。检测2组血生化指标及血清miR-19b-3p水平,应用简明精神状态(MMSE)量表评估认知功能,分析血清miR-19b-3p与认知功能的相关性。结果观察组血清肌酐(Scr)水平高于对照组,肾小球滤过率(e GFR)水平低于对照组(P <0. 01)。观察组MMSE量表各维度评分均低于对照组,血清miR-19b-3p水平高于对照组(P <0. 05)。合并认知功能障碍组血清miR-19b-3p水平高于未合并认知功能障碍组(P <0. 05)。急性腔隙性脑梗死患者血清miR-19b-3p水平与血清Scr、e GFR水平无明显相关性(r=0. 260、-0. 184,P> 0. 05),与MMSE量表评分呈明显负相关(r=-0. 726,P <0. 05)。结论血清miR-19b-3p水平可作为评价急性腔隙性脑梗死患者认知功能的非侵入性指标,临床应给予早期识别、合理干预,对改善患者预后生活质量有重要意义。

Objective To analyze correlation between serum miR-19b-3p level with cognitive function in patients with acute lacunar infarction. Methods A total of 96 patients with acute lacunar infarction admitted during February 2015 and February 2017 were selected as observation group, and other 60 healthy people taking medical examinations at the same period were selected as control group. in two groups, serum miR-19b-3p levels were detected, and cognitive function was assessed by using mini-mental state examination (MMSE) rating scale, and correlation between serum miR-19b-3p with cognitive function were analyzed. Results In observation group, serum creatinine (Scr) level was significantly higher, while glomerular filtration rate (GFR) was significantly lower than those in control group ( P <0.01);scores of MMSE rating scale were significantly lower, while serum miR-19b-3p level was significantly higher than those in control group ( P <0.05). Serum miR-19b-3p level in combined with cognitive disorder group was significantly higher than that in non- combined with cognitive disorder group ( P <0.05). There were no significant correlations between serum miR-19b-3p level with serum Scr and GFR levels ( r =0.260,-0.184, P >0.05), but serum miR-19b-3p level was negatively correlated with MMSE score in patients with acute lacunar infarction ( r =-0.726, P <0.05). Conclusion Serum microRNA-19b-3p level may be used as a non-invasive index to evaluate cognitive function in patients with acute lacunar infarction. Early identification and reasonable intervention are of great significance to improve prognosis and life quality of patients in clinic.