艾司西酞普兰治疗老年抑郁症临床观察

Clinical Observation of Escitalopram in Treatment of Elderly Patients with Depression

目的观察艾司西酞普兰治疗老年抑郁症的临床效果及安全性。方法选择2017年10月—2018年5月收治的老年抑郁症患者73例,根据治疗方法分为观察组38例及对照组35例。观察组给予艾司西酞普兰,对照组给予米氮平。2组均治疗6周,观察临床疗效、汉密尔顿抑郁量表(HAMD)评分及药物不良反应。结果 2组治疗后HAMD评分均较治疗前降低(P <0. 05),但2组间比较差异无统计学意义(P> 0. 05)。2组总有效率比较差异无统计学意义(P> 0. 05)。观察组不良反应发生率低于对照组(P <0. 05)。结论艾司西酞普兰治疗老年抑郁症效果好,且安全性较高。

Objective To observe clinical efficacy and safety of Escitalopram in treatment of elderly patients with depression. Methods A total of 73 elderly patients with depression admitted during October 2017 and May 2018 were divided into observation group ( n =38) and control group ( n =35) according to therapeutic methods. Observation group was given Escitalopram, while control group was given Mirtazapine. All patients were treated for 6 weeks. Clinical efficacy, hamilton rating scale for depression (HAMD) score and incidence rate of adverse drug reactions were observed in two groups. Results After treatment, HAMD scores were significantly lower than those before treatment in two groups ( P <0.05), but there was no significant difference in the score between two groups ( P >0.05). There was no significant difference in the total effective rate between two groups ( P >0.05). Incidence rate of adverse reactions in observation group was significantly lower than that in control group ( P <0.05). Conclusion Escitalopram is effective and safe in treatment of elderly patients with depression.