摘要
目的探索小牛血清去蛋白提取物联合美沙拉嗪对急性放射性肠炎的防治作用,寻找能够有效防治各级放射性直肠炎的理想药物。方法选择2017年1-7月在我院就诊的114例直肠癌术前新辅助治疗患者,随机分为观察组和对照组,每组57例。观察组行放疗+小牛血清去蛋白提取物联合美沙拉嗪保留灌肠,对照组行放疗+美沙拉嗪栓剂保留灌肠。观察两组治疗前后相关血液指标和临床指标的变化。结果治疗后2~5周,观察组C反应蛋白水平低于对照组,两组比较差异有统计学意义(P<0.05)。观察组和对照组的轻度放射性肠炎(Ⅰ~Ⅱ级)发生率分别为22.8%(13/57)和52.7%(30/57),重度放射性肠炎(Ⅲ~Ⅳ级)发生率分别为1.7%(1/57)和12.3%(7/57),两组比较差异有统计学意义(P<0.05)。观察组和对照组因不良反应致治疗中断的比例分别为1.7%(1/57)和12.3%(7/57),两组比较差异有统计学意义(P<0.05)。结论小牛血清去蛋白联合美沙拉嗪栓剂灌肠给药较单用美沙拉嗪栓剂灌肠明显减少了放射性直肠炎的发生,并且降低了C反应蛋白水平,保证了治疗的延续性。
Objective To explore the preventive and therapeutic effects of deproteinized extract of calf blood(DECB)combined with mesalazine on radiation proctitis,and to find an ideal combination of drugs that can effectively prevent and treat various radiation proctitis.Methods Totally 114 patients with rectal cancer treated with neoadjuvant therapy in our hospital from January to July 2017 were selected.They were randomly divided into observation group and control group,57 cases in each group.Patients in observation group received radiotherapy + DECB + mesalazine suppository retention enema,while patients in control group received radiotherapy combined with mesalazine suppository retention enema.The changes of blood and clinical indexes before and after treatment in the two groups were observed.Results The level of C-reactive protein(CRP)of observation group was lower than that of control group at 2 ~ 5 weeks after treatment(P<0.05).The incidence rate of mild acute proctitis(levelⅠ~Ⅱ)in observation group and control group were 22.8%(13/57)and 52.7%(30/57),and those of severe acute proctitis(level Ⅲ~Ⅳ)were 1.7%(1/57)and 12.3%(7/57),there being significant difference between the two groups(P<0.05).The proportion of treatment interruption due to adverse reactions in observation group and control group was 1.7%(1/57)and 12.3%(7/57),respectively,and there being significant difference between the two groups(P<0.05).Conclusion Compared with mesalazine suppository retention enema,DECB combined with mesalazine suppository retention enema can significantly reduce the occurrence of radiation proctitis and decrease the level of CRP,and therefore,g uarantee the continuity of treatment.
作者
庄玲
ZHUANG Ling(Liaoning Provincial Tumor Hospital,Shenyang 110042,China)
出处
《实用药物与临床》
CAS
2019年第4期413-416,共4页
Practical Pharmacy and Clinical Remedies
关键词
直肠癌
同步放化疗
放射性直肠炎
美沙拉嗪
栓剂
小牛血清去蛋白提取物
Rectal cancer
Concurrent radiotherapy and chemotherapy
Radiation proctitis
Mesalazine
Suppository
Deproteinized extract of calf blood