一种改进的基因功能网络术语相似度计算方法

An Improved Similarity Calculation Method of Terminology of Gene Function Network

阐述现有基因术语间语义相似度计算方法,提出基于融合高斯核函数的重启随机游走的基因本体术语相似度算法(Random Walk with Restart-based Similarity Measure, RWRSM),测试算法性能并进行分析,结果表明该算法优于其他算法,可以提高准确性及稳定性。

The paper elaborates on the existing semantic similarity calculation methods between Gene Ontology( GO) terminologies,puts forward the Random Walk with Restart-based Similarity Measure(RWRSM) based on the Gauss Kernel Function, tests the performance of the calculation method and carries out analysis. The result shows that the calculation method is superior to any other calculation method since it increases the accuracy and stability.