中晚期宫颈癌常规放疗加腔内近距离治疗同步体外高频热疗联合中药治疗的疗效研究

Efficacy of Conventional Radiotherapy Plus Intracavitary Brachytherapy Combined with External High Frequency Hyperthermia Combined with Traditional Chinese Medicine in Treatment of Advanced Cervical Cancer

目的:观察对于中晚期宫颈癌常规放疗加腔内近距离治疗同步体外高频热疗联合中药治疗的疗效分析。方法:将在我院近期(2015年1月至2017年1月)收治经病理学诊断确诊为宫颈癌Ⅱb～Ⅲb期患者66例,随机数字法分成实验组与对照组,常规放化疗体外增敏热疗加中药的实验组(n=33),常规放化疗对照组(n=33)。比较两组患者近期疗效、毒副反应,随访结束评估一年生存率及生活质量调查。结果:实验组总有效率为90.91%,对照组总有效率为69.7%,实验组患者毒副反应率为9.09%,对照组为36.64%,经治后随着随访时间增加生活质量评分也随之增加,且实验组明显高于对照组,而实验组随访一年生存率为100%,对照组仅为72.73%,差异具有统计学意义(P<0.05)。结论:对于中晚期宫颈癌患者而言,常规放疗加腔内近距离治疗,同步体外高频热疗联合中药治疗,可获得较好的近期疗效,较低的毒副反应提高患者一年生存率,提高患者治疗后生活质量,效果理想。

Objective: To observe the efficacy of conventional radiotherapy combined with intracavitary brachytherapy combined with external high frequency hyperthermia combined with traditional Chinese medicine in the treatment of advanced cervical cancer. Methods: 66 patients with stage II b ~ III B of cervical cancer diagnosed by pathological diagnosis were treated in our hospital (Jan. 2015 to Jan. 2017). The random digital method was divided into experimental group and control group. The experimental group (n=33) and conventional radiotherapy and chemotherapy (n=33) were used in the experimental group (n=33). The short-term efficacy, side effects, and the end of follow-up were evaluated for the two year survival rate and quality of life. Results: In the experimental group, the rate of CR was 90.91%, the rate of PR was 33.33%, the rate of NC was 9.09%, the total effective rate was 90.91%, the rate of CR in the control group was 90.91%, the rate of PR was 33.33%, the rate of NC was 9.09%, the total effective rate was 90.91%. The side reaction rate of the experimental group was 9.09% and the control group was 36.64%. The increase of the quality of life after the treatment was also increased with the follow-up time, and the experimental group was also obviously improved. The survival rate of the experimental group was 100%, while that of the control group was only 72.73%. The difference was statistically significant (P < 0.05). Conclusion: For children with middle and advanced cervical cancer, conventional radiotherapy combined with intracavity close range therapy, combined with external high-frequency thermotherapy combined with traditional Chinese medicine can achieve better short-term effect. Lower toxic and side effects can improve the one year survival rate, improve the quality of life after treatment and result in ideal results.