两种中药保留灌肠技术治疗溃疡性结肠炎的疗效观察

Clinical Observation of Two Kinds of Enema Techniques with Traditional Chinese Medicine in the Treatment of Ulcerative Colitis

目的:观察不同浓度的通灌汤结合止血灌肠散分别采用气药灌肠法和传统灌肠法治疗溃疡性结肠炎的临床疗效。方法:将180例溃疡性结肠炎患者用随机数字表法分为6组,每组30例,分别为气药灌肠低剂量组(气药低组)、气药灌肠中剂量组(气药中组)、气药灌肠高剂量组(气药高组)、传统灌肠低剂量组(传统低组)、传统灌肠中剂量组(传统中组)、传统灌肠高剂量组(传统高组),治疗15 d为1个疗程,连续治疗2个疗程,观察6组患者治疗前后各症状积分、中医证候疗效、黏膜组织学评分。结果:治疗后,各组患者症状积分均低于治疗前,且气药中剂量组低于其余各组,差异均有统计学意义(P<0.05)。治疗后气药中组中医证候疗效为96.7%,高于其余各组,差异均有统计学意义(P<0.05)。治疗后,各组肠镜黏膜积分均低于治疗前,且气药中组明显低于其余各组,差异均有统计学意义(P<0.05)。治疗后气药高组黏膜组织学总有效率为96.7%,高于其余各组,差异均有统计学意义(P<0.05)。结论:应用适量浓度的通灌汤结合止血灌肠散气药灌肠法保留灌肠治疗溃疡性结肠炎疗效显著,且优于传统灌肠法。

Objective: To observe the clinical curative effect of different concentrations of Tongguan Decoc-tionusing traditional Chinese medicine enema technology, gas-herb enema method and traditional enema method in the treatment of ulcerative colitis. Methods: 180 cases of ulcerative colitis were randomly divided into 6 groups, respectively, gas-herb enema with Tongguan decoction low dose group, gas enema with Tongguan De-coction dose group, gas enema with Tongguan decoction high dose group, traditional enema Tongguan decoction low dose group, traditional enema. Irrigation dose decoction, traditional enema Tongguan decoction high dose group, 30 patients in each group were treated for 4 weeks, and the clinical efficacy was observed. Results: After treatment, the symptom score of each group was lower than that before treatment, and the middle dose group was lower than the other groups, the difference was statistically significant (P<0.05). After treatment, the curative effect of TCM syndromes in gas-herb group was 96.7%, higher than that in other groups, the difference was statistically significant (P<0.05). After treatment, the intestinal endoscopy mucosal score of each group was lower than that before treatment, and that of the gas-herb group was lower than that of the other groups, the differ-ence was statisticeilly significant (P<0.05). After treatment, the total effective rate of mucosal histology was 96.7% in gas group, which was higher than that in other groups (P<0.05). Conclusion: Retention enema with appropriate concentration of Tongguan decoction combined w 让h hemostasis enema and dispersing gas-herb enema has a sig-nificant effect on ulcerative colitis, and is superior to traditional enema.