摘要
以芳香醛、苯乙酮和芳香胺为原料,乙醇作溶剂,使用蒙脱土负载碘催化Mannich反应,合成了β-氨基羰基衍生物(4a～4h),收率89.9%～98.5%,其结构经~1H NMR和IR确证。催化剂循环使用3次,4a收率70.4%。
β-Aminocarbonyl derivatives( 4a^4h ) were synthesized by ultrasound assist Mannich reaction catalyzed by loaded Iodine using aromatic aldehyde, acetophenone, aromatic aniline as starting materials. The yields of 4a^4h were 89.9%~98.5%. The structures were confirmed by ^1H NMR and IR. The yield of 4a was 70.4% after the catalyst recycle for three times.
作者
吴小云
李梅
杜莹
陈卓
尹晓刚
WU Xiao-yun;LI Mei;DU Ying;CHEN Zhuo;YIN Xiao-gang(Key Laboratory of Functional Materials Chemistry of Gui Zhou Province, School of Chemistry and Materials Science, Gui Zhou Normal University, Guiyang 550001, China)
出处
《合成化学》
CAS
北大核心
2019年第4期311-315,共5页
Chinese Journal of Synthetic Chemistry
基金
贵州省科技厅科技支撑项目(黔科合支撑[2016]2311)
贵州省科学技术基金资助项目(黔科合字[2009]2007)
关键词
曼尼希反应
超声
蒙脱土
催化
合成
Mannich reaction
ultrasound
montmorillonite
catalysis
synthesis
