行TACE治疗后原发性肝细胞癌患者预后的影响因素

Prognostic Factors of Patients with Primary Hepatocellular Carcinoma Treated with TACE

目的探讨行TACE术后的原发性肝细胞癌患者预后的影响因素。方法回顾性分析2006年3月至2009年10月于云南省肿瘤医院介入医学科就诊的108例原发性肝细胞癌(HCC)患者临床资料,通过建立Cox回归模型,探究各因素对行TACE治疗的HCC患者预后的影响。结果 Cox回归模型显示,TACE次数对HCC患者的生存情况影响的P值为0.007<0.05,具有统计学差异,行多次TACE术者的生存风险为行单次TACE术者的0.465倍;癌灶分布于肝左右叶P值为0.016,生存风险较单分布于肝左或肝右叶高;NLR>3.97者P值约为0.05。结论 TACE次数、癌灶分布情况、NLR对行TACE治疗HCC患者的生存情况有显著影响。

Objective To investigate the prognostic factors of primary hepatocellular carcinoma(HCC after TACE1. Methods The clinical data of 108 patients with primary hepatocellular carcinoma(HCC) from March 2006 to October 2009 in the Department of Interventional Medicine of Yunnan Cancer Hospital were analyzed retrospectively. The Cox regression model was established to explore the influence of various factors on the prognosis of HCC patients treated with TACE. Results The Cox regression model showed that the number of TACE had a significant effect on the survival of HCC patients(P<0.05), and the survival risk of the patients undergoing multiple TACE operations was significantly lower than that of the control group. P value of whose cancer located in the whole liver was 0.016, and the survival risk was higher than those distributed only in one liver lobe. P value of NLR>3.97 was 0.050. Conclusion The number of TACE and the distribution of cancer foci have significant effect on the survival of HCC patients treated with TACE.