骨性关节炎相关滑膜炎症研究进展

Advances in Synovitis Associated with Osteoarthritis

骨性关节炎(osteoarthritis,OA)是影响滑膜关节(膝,髋,手指远端,脊柱关节)的常见慢性退行性疾病,病变常常影响整个关节组织,以关节软骨的降解、关节边缘骨赘形成和滑膜病变为特征。以往的研究和治疗重点大多在关节软骨病变,而越来越多的研究显示滑膜的炎性病变在骨性关节炎整个病程中起重要作用,滑膜炎症以及与滑膜相关的致炎因子诱导的关节软骨的降解和破坏,促进了骨性关节炎的发展。滑膜病变在骨性关节炎的发生发展中扮演了重要角色,因此,滑膜炎症可以作为骨性关节炎治疗的一个关键靶点。

Osteoarthritis(OA) is a common chronic degenerative disease affecting synovial joints(knee,hip, distal finger, spinal joint). Lesions often affect the entire joint tissue, with the degradation of articular cartilage, joint bone Ankle formation and synovial lesions are characteristic. Most of the previous research and treatment focuses on articular cartilage lesions, more and more studies have shown that inflammatory lesions of the synovial membrane play an important role in the whole course of osteoarthritis,synovial inflammation and induction of inflammatory factors associated with synovium. The degradation and destruction of articular cartilage promotes the development of osteoarthritis. Synovial lesions play an important role in the development of osteoarthritis. Therefore,synovial inflammation can be a key target for the treatment of osteoarthritis.