慢性阻塞性肺疾病发病机制的研究进展

Progress in the Pathogenesis of Chronic Obstructive Pulmonary Disease(COPD)

慢性阻塞性肺疾病(chronic obstructive pulmonary disease, COPD)是呼吸系统中的常见病和多发病,其发病率和致死率居高不下。根据WHO调查数据显示,预计到2020年, COPD将成为全球第三大致死病因。COPD的形成与发展涉及众多因素,包括遗传因素和环境因素等。COPD的发病机制至今未明,氧化应激、炎症机制、蛋白酶/抗蛋白酶失衡以及细胞凋亡与之密切相关。另外,自身免疫反应、微生物组的变化以及无效的受损修复在COPD的发病机制中同样具有关键作用。因此,深入了解并研究COPD的发病机制对预防与治疗该疾病具有重要意义。

Chronic obstructive pulmonary disease(COPD) is a common and frequently-occurring disease with high morbidity and mortality. According to WHO, COPD will become the third leading cause of death worldwide in 2020. The occurrence and development of COPD is multifactorial and the risk factors of COPD include genetic and environmental factors. The pathogenesis of COPD remains unclear. The proposed pathogenesis of COPD includes oxidative stress, immunological mechanisms, proteinase-antiproteinase imbalance and apoptosis.Besides, autoimmune process, deviated microbiota and destroyed repair mechanisms are also playing important roles in it. Further understanding and exploring the pathogenesis of COPD is crucial for prevention and treatment of the disease.