成纤维细胞生长因子与抑郁症的相关性研究进展

Progress of the correlation between fibroblast growth factor and depression

抑郁症是公共卫生的一个主要问题,但目前抑郁症的发病机制仍不明确。近年来研究发现多种成纤维细胞生长因子(FGF)系统成员与抑郁症存在相关性。这些信号分子可能有望成为抑郁症的诊断和预后的生物标志物,并可能为抑郁症的治疗提供新的药物靶点。因此,本文对FGF系统的某些成员与抑郁症的相关性作一综述。

Depression is a major problem in public health. However,the mechanism of the pathogenesis of depression is still unclear. Recent studies reported that a variety of fibroblast growth factor( FGF) system members are associated with depression. These signaling molecules may be expected to become biomarkers for the diagnosis and prognosis of depression,and may provide new drug targets for the treatment of depression. In the present paper,we reviewed the correlation between certain members of fibroblast growth factor system and depression.