米力农和硫酸镁治疗新生儿肺动脉高压的疗效比较

Comparison of efficacy of millinon and magnesium sulfate in the treatment of neonatal pulmonary hypertension

目的评价米力农和硫酸镁治疗肺动脉高压的有效性及安全性。方法回顾性分析西安高新医院2011年1月至2016年12月收治的新生儿持续肺动脉高压(PPHN)45例,按治疗方法不同分别纳入米力农组22例和硫酸镁组23例。对比分析两组PPHN治疗有效率,不良反应发生情况。结果米力农组治疗有效22例(95%),硫酸镁组治疗有效20例(91%),差异无统计学意义(P>0.05),在不良反应发生情况方面,米力农组无不良反应发生,硫酸镁组发生了15例,差异有统计学意义(P<0.05)。结论米力农和硫酸镁组治疗PPHN临床治疗效果相似,但米力农治疗后未见不良反应发生。

Objective To evaluate the efficacy and safety of Millinon and Magnesium sulfate in the treatment of pulmonary hypertension.Methods 45 cases of neonatal persistent pulmonary hypertension(pulmonary hypertension of the NEW-BORN,PPHN)admitted to Xi’an High-tech Hospital from January 2011 to December 2016 were analyzed retrospectively.According to different treatment methods,22 cases were included in Millinon group and 23 cases in magnesium sulfate group.The treatment efficiency,adverse reactions occurred of the two groups of PPHN were compared.Results 22 Cases(95%)were effective in the treatment of Millinon Group,20 cases(91%)were effective in the treatment of magnesium sulfate group,with no statistically significant difference(P>0.05).The incidence of adverse reactions was significantly lower than that of magnesium sulfate group.There was no adverse reaction in the Millinon group,15 cases occurred in magnesium sulfate group(P=0.05).Conclusion The therapeutic effect of Milli-non and Magnesium sulfate group on PPHN is similar,however,no adverse reactions occurred after Millinon treatment.