摘要
脂蛋白脂酶(lipoprotein lipase,LPL,EC 3.1.1.34)是降解甘油三酯(triglyceride,TG)的限速酶,其活性降低是引起高甘油三酯血症的主要原因。LPL受到众多因素调控,包括血管生成素样蛋白、载脂蛋白、miRNAs和lncRNAs等。LPL是影响动脉粥样硬化(atherosclerosis,AS)发生发展的重要因素,其分布位置不同决定了LPL具有促AS或抗AS作用。该文重点阐述了LPL调控机制对AS的影响,有助于进一步揭示LPL在脂质代谢及AS发生发展中的作用。
Lipoprotein lipase(LPL, EC 3.1.1.34) is a rate-limiting enzyme and responsible for the degradation of triglyceride(TG). The lower activity LPL is tend to initiate hypertriglyceridemia(HTG). Many factors have been found to regulate the expression and activity of LPL, including angiopoietin-like proteins, apolipoprotein, miRNAs,and lncRNAs. The role of LPL in the development and progression of atherosclerosis(AS) is up to the distribution of LPL. Different LPL distribution results in its different role(promoter or suppressor) in AS. This review aimed to summary the role of LPL in AS, which may further reveal the role of LPL in lipid metabolism and provide a new target to prevent AS.
作者
何林昊
王宗保
唐朝克
HE Lin-Hao;WANG Zong-Bao;TANG Chao-Ke(Institute of Cardiovascular Diseases,Key Laboratory for Atherosclerology of Hunan Province,Medical Research and Experiment Center,University of South China,Hengyang 421001,China;Hunan Collaborative Innovation Center of Molecular Target New Drug Research,School of Pharmaceutical Science,University of South China,Hengyang 421001,China)
出处
《生命科学》
CSCD
北大核心
2019年第2期166-171,共6页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81770461)
