摘要
小檗碱(berberine,BBR)是中药黄连的主要活性成分,属于异喹啉类生物碱,具有广谱抗菌作用。近年来发现它还有降血糖、降血脂、免疫调节及改善充血性心力衰竭等药理作用。研究表明,BBR能够改善糖尿病相关疾病的症状,且作用广泛,不仅可影响编码基因的表达,还与miRNA和lncRNA等非编码基因关系密切,涉及糖脂代谢、肠道菌群等多个方面。该文拟就BBR调节糖脂代谢及其抗糖尿病活性的研究进展做一综述。
Berberine(BBR) is an isoquinoline alkaloid originally isolated from Chinese herb Coptis chinensis Franch(Huanglian), which has a broad-spectrum antibacterial effect as the main active ingredient of R. coptidis.Recently, it has been found that it has the pharmacological effects of lowering blood glucose, reducing blood lipid,regulating immunity and improving the symptom of congestive heart failure, etc. But the mechanisms remain to be studied. Previous researches show that BBR may improve the symptoms of type 2 diabetes(T2D) and its complications, and then exert global anti-diabetic effects by regulating a few coding genes, but also noncoding RNAs, such as miRNAs and lncRNAs. In this paper, the research progress of BBR regulating genes expression on glucolipid metabolism and its anti-diabetic activities was reviewed.
作者
李东伟
邵梦寒
葛传慧
周忍
丁晨宵
于立恒
陈德宇
LI Dong-Wei;SHAO Meng-Han;GE Chuan-Hui;ZHOU Ren;DING Chen-Xiao;YU Li-Heng;CHEN De-Yu(School of Food and Biological Engineering,Fuyang Normal College,Fuyang 236037,China;Anhui Province Anti-aging Chinese Herbal Medicine Engineering Technology Research Center,Fuyang 236037,China;Conservation Biology Research Center,Fuyang Normal College,Fuyang 236037,China;Department of Integrated Chinese and Western Medicine,Fuyang People's Hospital,Fuyang 236000,China)
出处
《生命科学》
CSCD
北大核心
2019年第2期201-208,共8页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(81771567)
安徽省高校自然科学研究重点项目(KJ2018A0350
KJ2018A0331)
2017年度第二批阜阳市政府-阜阳师范学院横向合作一般科研项目(XDHX201736)
2016年度阜阳师范学院博士科研启动费项目
大学生创新创业训练计划项目(201710371038
201710371034)
关键词
小檗碱
糖脂代谢
调节
抗糖尿病活性
berberine
glucolipid metabolism
regulating
anti-diabetic activities
