斑马鱼作为骨骼疾病模型的研究进展

Research progress of zebrafish models of bone diseases

斑马鱼作为一种优良的动物模型已被广泛应用于人类相关疾病机理及药物筛选的研究。由于斑马鱼骨骼发育过程和调控机制与哺乳动物高度保守,目前已成功构建斑马鱼骨骼疾病模型。本文首先介绍斑马鱼骨骼发育过程和分子调控机制,并对斑马鱼模型骨骼研究的基本方法及在骨骼药物筛选中的研究现状进行分析和总结,以期对斑马鱼作为骨骼疾病模型进行药物筛选或基础研究提供参考。

Zebrafish has been widely used as an animal model for human disease research and drug screening. Bone disease models have been successfully established in zebrafish because of its highly conserved molecular mechanism of osteogenesis with mammals. Here, we introduce the processes and regulatory networks of zebrafish osteogenesis, and then summarize the classical method for zebrafish bone research and the research status of drug screening for bone diseases. This information will provide a reference for drug screening and basic research using zebrafish bone disease models.