摘要
A型流感病毒(influenza A virus,IAV)感染人和动物,严重威胁公共卫生安全。动物模型在IAV研究中发挥着重要作用,不同的动物模型具有不同的优点和限制性。本文比较了雪貂与小鼠、豚鼠和非人灵长类动物模型的优点和限制性,突出说明雪貂在IAV研究中的重要性,并就雪貂在IAV致病性、传播和疫苗研发中的研究进展做了总结,以期为IAV的基础和应用研究提供参考。
Influenza A viruses (IAVs) infect humans and animals, and pose continuous threats to public health. Animal models have pivotal roles in IAV research, and different animal models have different advantages and limitations. We focused on the advantages and disadvantages of the use of ferrets, and compared them with those of mice, guinea pigs, and non-human primate models. We highlighted the important role of ferrets in IAV research. This paper briefly reviews the research progress in use of ferret models in the studies of pathogenesis, transmission and evaluation of IAVs. As such, it provides references for the basic and applied research of IAVs.
作者
马树杰
张博
孔宇飞
关云涛
MA Shujie;ZHANG Bo;KONG Yufei;GUAN Yuntao(State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2019年第2期254-260,共7页
Acta Laboratorium Animalis Scientia Sinica
基金
国家重点研发计划项目(2016YFC1201402)~~
关键词
A型流感病毒
雪貂
动物模型
致病性
传播
疫苗研发
influenza A virus
ferret
animal model
pathogenesis
transmission
vaccine development
