丹红注射液对急性缺血性脑卒中患者神经功能和血清炎症因子的影响

Effect of Danhong Injection on Neurological Function and Serum Inflammatory Factor in Patients with Acute Ischemic Stroke

目的:探讨丹红注射液对急性缺血性脑卒中(AIS)的临床疗效及对患者血清hs-CRP和神经功能的影响。方法:选取83例AIS并随机分为对照组41例和试验组42例。对照组给予常规AIS治疗;试验组在对照组的基础上加用丹红注射液20mL+0.9%NS250mL持续静脉输注28(1。治疗28d后进行疗效、卒中量表(NIHSS)、血清高敏C反应蛋白(hs-CRP)水平比较。结果:治疗28d后试验组和对照组总有效率分别为66.7%和39.0%,试验组显著高于对照组(P<0.05);治疗后试验组和对照组NIHSS分别为(11.35±3.88)和(14.65±4.01),血清hs-CRP分别为(7.21±2.21)ng/mL和(10.66±2.36)ng/mL,两组NIHSS评分和血清hs-CRP均显著降低(P<0.05),且治疗后试验组低于对照组(P<0.05)。结论:丹红注射液可改善AIS患者神经功能、降低全身炎症反应和致残率。

ObjectivecTo assess the efficacy, safety and impact on hs-CRP of Danhong injection on neural function deficiency NHISS in patients with acute AIS. Method:Eight three subjects with AIS recruited from Feb 2015 to Feb 2017 were randomly divided in to control group (n=41) and treatment group (n=42). Patients in the treatment group was given basic medical care such as blood pressure control, anti platelet, blood fat control and et al. And patients in the treatment group were given Danhong injection 20mL+0.9%NS 250 mL iv ggt 4-week beside the basic medical care. After 4 weeks treatment, the National Institute of Health stroke scale, mRS system and serum hs- CRP were taken to evaluate the recovery of neural function deficiency in AIS patients. Results:The total efficacy were 66.7% and 39.0% espectively, which demonstrated treatment higher (P<0.05);The NIHSS score and hs-CRP were significant reduced after 4 weeks treatment in the both treatment and control groups (P<0.05). ConclusionrDanhong injection can significantly improved the neural function deficiency ,reduce the systemic inflammatoi-y and residual rate.