调控毛囊发育的Wnt信号通路研究进展

Progress on Wnt Signaling Regulating Hair Follicle Development

毛囊周期性发育过程受多种分子及信号通路调控,Wnt信号通路就是其中之一。Wnt信号通路调控动物发育过程中的多个重要环节,包括细胞增殖、细胞迁移及细胞分化等,且在毛囊发育过程中发挥着重要的调控作用,这对动物毛皮质量的提高、人皮肤损伤的治疗及日益严重的脱发问题等提供更多的研究思路和实际应用价值。近年来,Wnt信号通路已成为信号通路研究中的热点之一。因此,论文就Wnt信号通路、毛囊发育及Wnt信号通路对毛囊发育的调控作用进行了综述,为广大科研人员的后续研究提供参考。

Follicle development process is regulated periodically by a variety of molecules and the signaling pathways,Wnt signaling pathway is one of them.Wnt signaling pathway regulates many important aspects of animal development,including cell proliferation,cell migration and cell differentiation,etc.,and plays an important regulatory role in the development of hair follicles,which would provide more research ideas and practical application value for improving the quality of animal skins,treating the damage of human skin and solving increasingly serious hair loss problems.Therefore,in recent years,Wnt signaling pathway has been one of the hot spots in the study of signaling pathways.Therefore,this article reviewed Wnt signaling pathways,the development of hair follicles,and the regulation of Wnt signaling pathways on the development of hair follicles,so as to provide a theoretical basis for the follow-up research of researchers.