类风湿关节炎急性期不同中医证候患者人口学特征和病情特点分析

Analysis on demographic characteristics and illness condition characteristics among patients with different TCM syndromes in acute phase of rheumatoid arthritis

目的探讨类风湿关节炎(RA)患者人口学特点和病情分布特征。方法选取2014年1月至2017年9月确诊RA患者300例为研究对象,对其进行辨证分型确定中医证候类型。比较不同证候患者性别、年龄、病程、关节疼痛和肿胀数、DAS28等级、红细胞沉降率(ESR)、C反应蛋白(CRP)、类风湿因子(RF)、抗环瓜氨酸肽抗体(CCP)等情况。结果不同性别RA患者中医证候构成比差异有统计学意义(P<0.05),不同性别RA患者不同中医证候病程、年龄差异有统计学意义(P<0.05)。不同中医证候RA患者ESR、CRP、RF、CCP、关节压疼数和关节肿胀数差异有统计学差异(P<0.05),关节压疼数和关节肿胀数最多的为湿热痹阻证。不同中医征候的类风湿关节炎患者病情评价(DAS28等级)比较差异有统计学意义(P<0.05)。结论 RA患者的性别、年龄、病程对中医证候影响明显,不同中医证候的临床表现和实验室指标差异明显。

Objective To discuss the demographic characteristics and illness condition distribution characteristics among the patients with rheumatoid arthritis(RA).Methods A total of 300 patients with RA in the hospital from January 2014 to September 2017 were selected as the study subjects and conducted the typing of syndrome for determining the type of TCM syndrome.The gender,age,disease course,DAS28 grade,ESR,CRP,RF CCP at the active stage were compared among different types of TCM syndrome.Results The constituent ratio of TCM syndromes had statistical difference between the different genders of RA patients(P<0.05).The disease course of different TCM syndromes and age had statistical difference between the different sexes of RA patients(P<0.05).ESR,CRP,RF and CCP,number of joint pain and swelling had statistical difference among the RA patients with different TCM syndromes(P<0.05).The most common symptoms of joint pain and joint swelling are heat arthralgia syndrome.The DAS28 scoring grade had statisticl difference among different TCM syndromes(P<0.05).Conclusion The influence of gender,age and disease course on TCM syndromes is most obvious and the clinical manifestations and laboratory indicators have significant differences among different TCM symptoms.