Graves病易感基因研究进展

Research progress on the Graves' disease susceptibility genes

Graves病(Graves' disease,GD)是最常见的器官特异性自身免疫病之一。GD作为甲状腺功能亢进症最常见的临床类型,其病因涉及遗传和环境等多个方面,但是其具体的发病机制目前尚未完全阐明。随着人类全基因组关联研究(Genome-Wide Association Study,GWAS)的广泛开展,目前已鉴定出多个基因参与了GD的发生。本文就GD易感基因的研究进展进行综述,初步探讨GD发病的遗传学机制。

Graves’disease (GD),the most common clinical type of hyperthyroidism,is a common organ-specific autoimmune disease.Although its etiology involves genetic and environmental factors,the exact pathogenesis of GD remains unclear.Extensive genome-wide association studies (GWAS) have identified various genes that contribute to the development of GD.This article reviews progress in our identification of susceptibility genes for GD,and provides a preliminary discussion on the genetic mechanism that promote GD onset.