摘要
Graves病(Graves' disease,GD)是最常见的器官特异性自身免疫病之一。GD作为甲状腺功能亢进症最常见的临床类型,其病因涉及遗传和环境等多个方面,但是其具体的发病机制目前尚未完全阐明。随着人类全基因组关联研究(Genome-Wide Association Study,GWAS)的广泛开展,目前已鉴定出多个基因参与了GD的发生。本文就GD易感基因的研究进展进行综述,初步探讨GD发病的遗传学机制。
Graves’disease (GD),the most common clinical type of hyperthyroidism,is a common organ-specific autoimmune disease.Although its etiology involves genetic and environmental factors,the exact pathogenesis of GD remains unclear.Extensive genome-wide association studies (GWAS) have identified various genes that contribute to the development of GD.This article reviews progress in our identification of susceptibility genes for GD,and provides a preliminary discussion on the genetic mechanism that promote GD onset.
作者
杜娟
王欣
谭贵琴
梁钟智
于红松
姚新生
DU Juan;WANG Xin;TAN Guiqin;LIANG Zhongzhi;YU Hongsong;YAO Xinsheng(Department of Immunology,Special Key Laboratory of Gene Detection and Therapy of Guizhou Province,Zunyi Medical University,Zunyi 563000,China;Department of BasicMedical Education,Zunyi Medical University,Zunyi 563000)
出处
《中国比较医学杂志》
CAS
北大核心
2019年第4期126-132,共7页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金面上项目(81670844)
贵州省科学技术基金重点项目(黔科合基础[2019]1464)
贵州省普通高等学校科技拔尖人才支持计划项目(黔教合KY字[2017]077)
遵义医科大学学术新苗培养及创新探索专项(黔科合平台人才[2017]5733-003)
遵义医科大学优秀青年人才计划(18-ZY-001)