防晒产品SPF值人体法与体外仪器法测定值一致性初探

Consistency of sunscreen SPF values measured by in vivo and in vitro methods

使用SPF 290S防晒指数测定仪测试防晒产品体外SPF值,比较其与人体法结果的一致性。对体外仪器法测定SPF值试验条件进行研究:选择PMMA板或HD6板为基板,样品涂样量2mg/cm^2,室温放置30min测定,该条件下能够得到较为稳定、重复性较好的体外SPF值测定结果。对产品的研究表明无机防晒剂会影响体外法和人体法的一致性,不含无机防晒剂的防晒产品,一致性好。含无机防晒剂的样品(包括氧化锌和二氧化钛),结果一致性较差。

SPF 290S was used to test the SPF value of sunscreen products in vitro,and the consistency with the results of in vivo method was compared.The experimental conditions for the determination of SPF values by in vitro instrument were studied.PMMA plate or HD6 plate were used as the substrate,samples were coated at a dose of 2 mg/cm^2,and placed in room temperature for 30 min.Under this condition,a more stable and reproducible SPF value in vitro measurement results could be obtained.Studies on the products define that inorganic sunscreen agents(including zinc oxide and titanium dioxide)can affect the consistency of in vitro and in vivo methods,and sunscreen products without inorganic show good consistency.Products containing inorganic sunscreen agents show poor consistency.