摘要
雌激素主要通过雌激素受体发挥抗抑郁作用。目前研究较多的是雌激素受体α(ERα)、雌激素受体β(ERβ)和G蛋白偶联雌激素受体(GPER)。三者在雌激素的抗抑郁作用中发挥不同的效应,其中GPER可能与雌激素的快速抗抑郁作用有关。深入了解雌激素受体的不同效应对于寻找治疗抑郁症的新靶点,充分发挥雌激素的抗抑郁作用,最大程度减少其不良反应具有重要意义。
Estrogen exerts antidepressant effects mainly through estrogen receptors.Presently,estrogen receptorα(ERα),estrogen receptorβ(ERβ)and G-protein coupled estrogen receptor(GPER)have been studied a lot.The three kinds of estrogen receptors play different roles in the antidepressant effects,and GPER may be related to the rapid antidepressant effects of estrogen.It is important to fully understand the different effects of estrogen receptors in order to find new targets for the treatment of depression,fully play the antidepressant effects of estrogen and reduce side effects.
作者
穆道周
胡桂芳
陈雷
张彤
MU Dao-zhou;HU Gui-fang;CHEN Lei;ZHANG Tong(Department of Acupuncture and Moxibustion,Jining First People’s Hospital,Jining 272011,China;Department of Rehabilitation Medicine,Jining First People’s Hospital,Jining 272011,China;the First Department of Mental Rehabilitation,Yankuang Group General Hospital;Department ofAcupuncture and Moxibustion,the Affiliated Hospital of Shandong University of Traditional Chinese Medicine)
出处
《天津医药》
CAS
北大核心
2019年第4期436-439,共4页
Tianjin Medical Journal
关键词
受体
雌激素
雌激素受体Α
雌激素受体Β
抑郁症
综述
G蛋白偶联雌激素受体
receptors,estrogen
estrogen receptorα
estrogen receptorβ
depressive disorder
review
G-protein coupled estrogen receptor
