miRNAs在脑缺血后病理生理机制中的作用

The research progress of miRNAs on pathophysiological mechanism after cerebral ischemia

脑缺血后病理生理机制复杂多样,单一药物或者基因靶点治疗很难形成有效的治疗。miRNAs是一类包含20～25个碱基的单链非编码RNA,可以对多种基因进行转录后调控。近年以来,发现有多种miRNAs在脑缺血后氧化应激、兴奋性毒性作用、免疫炎症、凋亡以及神经血管修复等多个方面有不同程度的作用。本文将针对miRNAs在脑缺血后病理机制中的作用进行综述。

The pathophysiological mechanism after cerebral ischemia is complex and diverse, and it is difficult to form an effective treatment with single drug or gene target therapy. miRNAs are a class of long single-stranded non-coding RNAs containing about 20-25 bases that allow for post-transcriptional regulation of multiple genes. In recent years, a variety of miRNAs have been found to have different effects on oxidative stress, excitotoxicity, immune inflammation, apoptosis, and neurovascular repairment after cerebral ischemia.This article will focus on the role of miRNAs in the pathogenesis of cerebral ischemia.