TIAM1蛋白在神经母细胞瘤中的表达及临床意义

Expression and Clinical Significance of TIAM1 in Neuroblastoma

目的:探索T淋巴瘤侵袭转移1蛋白(TIAM1)在神经母细胞瘤(NB)中的表达及临床意义。方法:运用免疫组化法检测61例神经母细胞瘤组织中TIAM1蛋白的表达,并分析其与NB患者临床病理特征及预后之间的关系。结果:TIAM1主要定位于细胞浆中,但也可表达在细胞核内,其表达与NB分化程度相关(χ~2=4.493,P=0.034),分化程度越高,表达越强;但其表达与年龄,INSS分期,肿瘤部位等无关。结论:TIAM1的表达与NB的分化程度呈正相关,有望成为NB潜在治疗靶点。

Objective: To explore the expression and clinical significance of TIAM1(T-lymphoma invasion and metastasis 1) in the neuroblastoma. Methods:The expression of TIAM1 protein in 61neuroblastoma tissues was detected by immunohistochemical method and its correlation with the clinicopathological characteristics and prognosis was analyzed. Results: TIAM1, mainly located in the cytoplasm, could also be expressed in the nucleus. Its expression was related to the degree of differentiation of NB(χ^2=6.205,P=0.013)the higher the differentiation degree, the stronger the expression. However, the expression was not related to age, INSS stage, tumor location and other factors. Conclusion: There is a positive correlation between the expression of TIAM1 and the differentiation of NB,which is expected to be a potential target for NB treatment.