血必净在治疗重症肺炎中的临床疗效研究进展

Progress in clinical efficacy of Xuebijing in treatment of severe pneumonia

目的研究血必净在治疗重症肺炎中的临床疗效研究进展。方法本研究纳入对象为我院治疗的74例重症肺炎患者,按入院顺序随机均分为观察组与对照组,对照组给予第三代抗生素、营养对症支持等常规治疗,观察组在此基础上联合血必净治疗。连续治疗12d后评价综合临床疗效,比较两组治疗前后血气指标以及血清炎性因子水平,脱机成功率。检测血清免疫球蛋白水平并观察影像学改变。结果观察组治疗7d、12d总有效率分别为75.68%、86.49%,对照组分别为54.05%、72.93%,观察组均显著高于对照组,(P<0.05),均无严重不良反应出现;两组治疗后血清IgM、IgG、IgA水平均显著增加,且治疗后观察组显著高于对照组,(P<0.05);两组治疗前后血气分析各项指标均显著改善,且治疗后观察组均优于对照组,差异具(P<0.05);两组治疗后血清降钙素(PCT)、肿瘤坏死因子α(TNF-α)、C反应蛋白(CRP)、白细胞介素6(IL-6)水平均显著降低,治疗后观察组显著低于对照组,(P<0.05);治疗后脱机率明显高于对照组。观察组7d、12d呼吸机脱机率分别为69.23%,96.15%,均显著高于对照组的48.28%、82.76%,(P<0.05)。结论联合血必净治疗能降低患者的炎性因子水平,改善重症肺炎患者血气分析指标,提高脱机率。

Objective To study the clinical progress of Xuebijing in treatment of severe pneumonia. Methods 74 patients with severe pneumonia who were treated in our hospital were randomly divided into the observation group and the control group according to the order of admission. The control group was given third-generation antibiotics and nutritional symptomatic support, and the observation group was combined with Xuebijing based on this. After 12 days of continuous treatment, the comprehensive clinical efficacy was evaluated. The levels of blood gas index and serum inflammatory factors and the the success rate of offline were compared before and after treatment, and serum immunoglobulin level was measured and imaging changes were observed. Results The total effective rate of the observation group was 75.68% and 86.49% at 7d and 12d, respectively, and 54.05% and 72.93% in the control group, respectively ( P< 0.05), and there was no serious adverse reactions occurred. The levels of serum IgM, IgG, and IgA were significantly increased after treatment in both groups, and the observation group was significantly higher than the control group after treatment ( P< 0.05). The blood gas analysis indexes were significantly improved before and after treatment, and the improvement was more pronounced in the observation group than in the control group ( P< 0.05). The levels of serum calcitonin (PCT), tumor necrosis factor alpha (TNF-α), C-reactive protein (CRP), and interleukin-6 (IL-6) after treatment decreased significantly in the two groups, and it was more pronounced in the observation group than in the control group after treatment ( P< 0.05). The successful offline rate after treatment was significantly higher in the observation group than in the control group. The ventilator off-line rate of the observation group at 7d and 12d were 69.23% and 96.15%, respectively, which were significantly higher than those of the control group (48.28%, 82.76%, P< 0.05). Conclusion The combination of Xuebijing treatment can reduce the level of inflammatory factors, improve blood gas analysis indicators and offline rate in patients with severe pneumonia.