舌癌动/静脉辅助化疗的临床疗效观察

The efficacy of adjuvant chemotherapy respectively via arterial and venous perfusion for tongue cancer

目的:观察选择性舌动脉灌注新辅助化疗对舌癌的疗效。方法:50例舌癌患者随机分成2组,A组(27例)选择性舌动脉新辅助化疗27例,B组(23例)静脉辅助化疗23例,化疗方案选择对舌癌高效敏感的DF方案(卡铂+5-氟尿嘧啶)。观察化疗前、后原发灶和颈转移淋巴结大小,评估化疗后原发灶临床有效率、原发灶和淋巴转移灶化疗后病理学分级。结果:原发灶化疗临床有效率:A组92.59%,B组69.56%(P<0.05);原发灶化疗后病理学分级中,III+IV级百分比:A组81.48%, B组39.11%(P<0.05);淋巴结转移灶化疗后病理学分级中,III+IV级百分比:A组80.00%, B组33.33%(P<0.05)。结论:选择性经舌动脉辅助化疗治疗舌癌较经静脉化疗提高了原发灶和转移淋巴结的控制率。

Objective:To evaluate the effects of the selective lingual artery in the treatment of tongue cancer underwent neoadjuvant chemotherapy DF program(Carboplatiin+5-FU).Methods:50 cases of tongue cancer were randomly divided into two groups.Group A(n=27):patients were treated by the lingual artery neoadjuvant chemotherapy.Group B(n=23):patients were treated by transvenous neoadjuvant chemotherapy.Before and after treatment primary foci and metastatic cervical lymph node size were examined,clinical efficiency and pathological classification were evaluated.Results:The clinical efficiency of group A and B was 92.59%and 69.56%(P<0.05),after treatment tumor pathological classification ofⅢ+Ⅳstage(%)of group A and B was 81.48%and 39.11%(P<0.05),cervical lymph node metastases with the pathological grade ofⅢ+Ⅳgrade(%)of group A and B was 80%and 33.33%(P<0.05),respectively.Conclusion:Neoadjuvant chemotherapy via lingual artery is more effectively than than that via vein chemotherapy in the treatment of tongue cancer.