网织血小板对急性白血病患者感染的早期诊断效果研究

Effect of reticulocyte on early diagnosis of infection in acute leukemia patients

目的探讨网织血小板(RP)检测在急性白血病患者感染的早期诊断价值。方法选取2017年1月至2018年2月于该院接受治疗的125例疑似感染的急性白血病患者为研究对象,根据病原学培养和影像学监测结果分析,将125例患者分为54例感染组和71例非感染组,同时选取于该院进行体检的52例健康人群作为对照组,分别检测并记录3组患者的各项血常规指标和生化指标,包括:患者外周血白细胞计数(WBC)、RP百分比(RP%)、中性粒细胞百分比(N%)、血小板计数(PLT)、降钙素原(PCT)、C反应蛋白(CRP),并计算RP的绝对值。结果感染组和非感染组血液中WBC、N%、PLT的水平明显低于对照组,感染组与对照组两组数据比较,差异有统计学意义(P<0.05)。感染组患者的RP%为8.9%,非感染组为4.8%,对照组为2.7%,感染组和对照组、非感染组组间数据比较,差异有统计学意义(P<0.05)。CRP用于诊断急性白血病感染时灵敏度为68.51%,特异度为83.10%;PCT用于诊断急性白血病感染时灵敏度为72.22%,特异度为84.51%;RP%用于诊断急性白血病感染时灵敏度为87.04%,特异度为90.14%,CRP、PCT两组数据与RP%数据比较,差异有统计学意义(P<0.05)。结论在早期诊断急性白血病感染方面,RP%相对于传统的炎性反应指标而言更具有诊断价值。

Objective To investigate the early diagnostic value of reticulocyte(RP)detection in acute leukemia patients.Methods 125 patients with suspected acute leukemia who were treated in the hospital from January 2017 to February 2018 were selected as the subjects,according to the results of pathogen culture and imaging monitoring,125 patients were divided into 54 cases and 71 non infection groups,At the same time,selected 52 healthy people as control group with physical examination in the hospital.The blood routine indexes and biochemical indexes of three groups were detected and recorded,including:Peripheral WBC count,percentage of net-woven platelets,neutrophil percentage(N%),platelet count(PLT),and Procalcitonin(PCT),C-reactive protein(CRP),and calculation of the absolute value of reticulated platelets.Results The contents of WBC,N%and PLT in the blood of infection Group and non infection group were significantly lower than those in control group,and the difference between the two groups was statistically significant(P<0.05).The percentage of the RP in the infected group was 8.9%,the non infection group was 4.8%,the control group was 2.7%,the difference between the infection group and the control group and the non infection group was statistically significant(P<0.05).The sensitivity of CRP to the diagnosis of acute leukemia infection was 68.51%and the specificity was 83.1%.The sensitivity of PCT for the diagnosis of acute leukemia infection was 72.22%and the specificity was 84.51%.The sensitivity of RP%for the diagnosis of acute leukemia infection was 87.04%,the specificity was 90.14%,CRP,and the difference between the two groups of PCT and RP%data was statistically significant(P<0.05).Conclusion In the early diagnosis of acute leukemia infection,the percentage of reticulocyte platelet is more valuable than the traditional inflammatory response index.