基于数据挖掘中药治疗性早熟的用药规律研究

Analysis on medication rule of Chinese medicine in treating precocious puberty based on data mining technology

目的挖掘中药治疗性早熟的组方用药特点及规律,提取新的处方。方法检索1979年1月1日～2018年10月1日中国期刊全文数据库、万方数据知识服务平台及维普中文科技期刊数据库收录的中药治疗性早熟的相关文献,运用中医传承辅助平台软件分析数据,提取结果。结果本研究纳入文献104篇,共计包含处方124例,得出应用频次较多的药物从高到低依次为知母、黄柏、牡丹皮、茯苓、生地黄、白芍等,得到基于关联规则的组方用药模式,进一步提取潜在的组方特点,并通过演化得到3味药的核心组合22个,用于新方聚类的核心组合10个,新处方5个。结论本研究分析了中药治疗性早熟的组方规律,并得出以补益肝肾、养阴清热,兼益气生津、行气散结为主要治则的新处方,为临床中药治疗本病提供依据,也为本病的新药开发提供参考。

Objective To dig out the characteristics and rules of Chinese medicine in treating precocious puberty, and extract new prescriptions. Methods Through retrieving CNKI, Wanfang Data Knowledge Service Platform, and VIP database on therapeutic precocious puberty of Chinese medicine from January 1, 1979 to October 1, 2018. And TCM inheritance support system was used to carry on the statistics analysis. Results Total 104 articles and 124 prescriptions were included in the reseach. It was concluded that the most frequently used drugs were Anemarrhena asphodeloides, Phellodendron amurense, Peony bark, Poria cocos, Rehmannia glutinosa and Paeonia lactiflora. Based on the association rules, the potential prescriptions have got. And then 22 core combinations of 3 flavors, 10 core combinations and 5 new prescriptions were explored from the database. Conclusion This study analyzes the prescription rule of Chinese medicine for treating precocious puberty, and obtains new prescriptions with the main principles of enrich liver and kidney, nourish yin and clear heat, boost qi and promote fluid and move qi and dissipate binds, which provides the basis for the clinical treatment of this disease by Chinese medicine, and also provides a reference for the development of new drugs for this disease.