益胃活血汤治疗气滞血瘀型急性胃炎的临床效果

Clinical effect of Yiwei Huoxue Decoction in treating acute gastritis with syndrome of qi stagnation and blood stasis

目的分析益胃活血汤治疗气滞血瘀型急性胃炎患者的临床效果。方法选择中国中医科学院望京医院2016年2月～2017年12月收治的120例气滞血瘀型急性胃炎患者,采用随机数字表法将其分为两组,对照组60例应用常规西医治疗,观察组60例在西医治疗的基础上结合益胃活血汤治疗。连续治疗2周后,比较两组临床疗效、中医症状积分、胃泌素和胃动素水平,以及安全性。结果观察组和对照组治疗后上脘疼痛、食欲下降及呕吐或呕血积分均明显低于治疗前(t=20.612、22.796、19.474,均P <0.05;t=16.095、18.724、15.163,均P <0.05),且观察组治疗后上脘疼痛、食欲下降及呕吐或呕血积分明显低于对照组(t=10.067、14.858、13.267,均P <0.05)。观察组总有效率明显高于对照组,差异有统计学意义(χ~2=5.55,P <0.05)。观察组和对照组治疗后胃泌素、胃动素水平均明显高于治疗前(t=5.353,11.277,均P <0.05;t=2.715、5.571,均P <0.05),且观察组治疗后胃泌素及胃动素水平明显高于对照组,差异有统计学意义(t=11.727、20.782,均P <0.05)。观察组总不良反应发生率低于对照组(χ~2=11.36,P <0.05)。结论益胃活血汤治疗气滞血瘀型急性胃炎可有效改善患者症状、胃肠功能,且安全可靠,应用价值显著。

Objective To analyze the clinical efficacy of Yiwei Huoxue Decoction in the treatment of acute gastritis patients with syndrome of qi stagnation and blood stasis. Methods One hundred and twenty acute gastritis patients with syndrome of qi stagnation and blood stasis admitted to Wangjing Hospital of China Academy of Chinese Medical Sciences from February 2016 to December 2017 were selected and divided into two groups by random number table method. 60 patients in the control group were treated with conventional Western medicine, 60 patients in the observation group were added with Yiwei Huoxue Decoction on the basis of Western medicine. After 2 weeks of continuous treatment, the clinical efficacy and TCM symptom scores, the levels of gastrin and motilin, and the safety were compared between the two groups. Results The scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group and the control group were all lower than those before treatment (t = 20.612, 22.796, 19.474, all P < 0.05;t = 16.095, 18.724, 15.163, all P < 0.05), and the scores of Shangwan pain, loss of appetite and vomiting or hematemesis in the observation group were lower than those of the control group after treatment (t = 10.067, 14.858, 13.267, all P < 0.05). The total effective rate of the observation group was higher than that of the control group, the difference was statistically significant (χ^2 = 5.55, P < 0.05). The levels of gastrin and motilin in the observation group and the control group were alll higher than those before treatment (t = 5.353, 11.277, all P < 0.05;t = 2.715, 5.571, all P < 0.05), and the levels of gastrin and motilin in the observation group were alll higher than those of the control group, the differences were statistically significant (t = 11.727, 20.782, all P < 0.05). The total incidence of adverse reactions in the observation group was lower than that in the control group (χ^2 = 11.36, P < 0.05). Conclusion Yiwei Huoxue Decoction can effectively improve the symptoms and gastrointestinal function of acute gastritis patients with syndrome of qi stagnation and blood stasis, it is safe and reliable, and it has significant application value.