保元汤合血府逐瘀汤对慢性心力衰竭患者心功能及炎性因子的影响

Effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure

目的探讨保元汤合血府逐瘀汤对慢性心力衰竭患者心功能及炎性因子的影响。方法选取重庆市垫江县中医院心病科2016年12月～2018年6月收治的慢性心力衰竭患者70例作为研究对象,按随机数字表法将其分为对照组和治疗组,各35例。对照组予以慢性心力衰竭规范化药物治疗,治疗组在对照组的基础上加用保元汤合血府逐瘀汤治疗,两组均以2周为1个疗程。比较两组患者临床疗效、中医证候疗效和治疗前后的血浆N末端前脑钠肽(NT-pro BNP)水平、炎性因子指标[超敏C反应蛋白(hs-CRP)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)]的变化情况。结果 1个疗程后,两组临床疗效和中医证候疗效比较结果显示,治疗组总有效率均明显高于对照组,差异有统计学意义(P <0.05)。治疗后,两组NT-pro BNP、hs-CRP、IL-6、TNF-α水平均较治疗前明显下降(P <0.01),且治疗组NT-pro BNP、hs-CRP、IL-6、TNF-α水平均明显低于对照组(P <0.05)。结论保元汤合血府逐瘀汤治疗慢性心力衰竭效果确切,可明显改善患者临床症状和中医证候,降低血浆NT-pro BNP水平和炎性因子水平。

Objective To investigate the effects of Baoyuan Decoction and Xuefu Zhuyu Decoction on cardiac function and inflammatory factors in patients with chronic heart failure. Methods Seventy patients with chronic heart failure who were admitted to Department of Cardiology, Traditional Chinese Medicine Hospital of Dianjiang County in Chongqing City from December 2016 to June 2018 were selected as research subjects, they were divided into the control group and the treatment group by random number table method, with 35 cases in each group. The control group was given standardized drug therapy for chronic heart failure, the treatment group was additionally treated with Baoyuan Decoction and Xuefu Zhuyu Decoction on the basis of the control group. Both groups took 2 weeks as a course of treatment. The clinical effect, TCM syndrome effect, plasma NT-proBNP levels and inflammatory factor indices [high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α)] were compared between the two groups before and after treatment. Results After one course of treatment, the results of comparison of clinical efficacy and TCM symptom efficacy between the two groups showed that the total effect rates of treatment group were all higher than those of control group, with statistically significant differences (P < 0.05). After treatment, the levels of NT-proBNP, hs-CRP, IL-6, TNF-α in the two groups were all lower than those before treatment (P < 0.01), and the levels of NT-proBNP, hs-CRP, IL-6, TNF-α in the tretment group were all lower than those in the control group (P < 0.05). Conclusion Baoyuan Decoction and Xuefu Zhuyu Decoction has reliable curative effects for patients with chronic heart failure, which can improve clinical symptoms and TCM syndromes significantly, and decrease the levels of NT-proBNP and inflammatory factors.