病毒清口服液联合奥司他韦治疗儿童热毒袭肺型流行性感冒的临床效果

The clinical effect of Virus-Clearing Oral Liquid combined with Oseltamivir in the treatment of influenza children with syndrome of heat toxicity attacking lung

目的分析病毒清口服液联合奥司他韦治疗儿童热毒袭肺型流行性感冒的临床效果。方法回顾性分析南宁市中医医院2018年1～8月收治的100例热毒袭肺型流行性感冒患儿的临床资料,根据治疗方法不同将其分为对照组和观察组,各50例。对照组患儿给予奥司他韦治疗,观察组患儿给予奥司他韦联合病毒清口服液治疗。分析两组患者治疗后的临床效果。结果观察组患儿总有效率高于对照组(P <0.05)。观察组患儿发热时间、咳嗽鼻塞好转时间、咽红肿痛好转时间、住院时间短于对照组(P <0.05)。治疗前,两组患儿白介素8(IL-8)、γ干扰素(IFN-γ)、C反应蛋白(CRP)水平比较,差异无统计学意义(P> 0.05)。两组患儿治疗后IL-8水平较治疗前上升,IFN-γ、CRP水平较治疗前下降,且观察组患者治疗后IL-8水平高于对照组,IFN-γ、CRP水平低于对照组,差异有统计学意义(P <0.05)。治疗前,两组患儿免疫球蛋白水平比较,差异无统计学意义(P> 0.05)。两组患者治疗后CD4^+、Ig A、Ig M水平较治疗前上升,CD8^+水平较治疗前下降,且观察组患者CD4^+、Ig A、Ig M水平高于对照组,CD8^+水平低于对照组,差异有统计学意义(P <0.05)。两组患儿不良反应发生率比较,差异无统计学意义(P>0.05)。结论奥司他韦联合病毒清口服液治疗儿童流行性感冒效果显著,其能明显改善临床症状,提高免疫力,且并发症较少,值得在临床上进一步推广应用。

Objective To analyze the clinical effect of Virus-Clearing Oral Liquid combined with Oseltamivir in the treatment of influenza children with syndrome of heat toxicity attacking lung. Methods A retrospective analysis was made on the clinical data of 100 cases of influenza children with syndrome of heat toxicity attacking lung admitted to Nanning Hospital of Traditional Chinese Medicine from January to August 2018. According to different treatment methods, they were divided into control group and observation group, with 50 cases in each group. The control group was treated with Oseltamivir, the observation group was treated with Oseltamivir combined with Virus-Clearing Oral Liquid. The clinical effects of the two groups after treatment were analyzed. Results The total effective rate of the observation group was higher than that of the control group (P < 0.05). The fever time, the improvement time of cough and nasal obstruction, the improvement time of throat swelling and pain and the hospitalization time of the observation group were shorter than those of the control group (P < 0.05). Before treatment, there were no significant differences in the levels of interleukin-8 (IL-8), interferon-γ(IFN-γ) and C-reactive protein (CRP) between the two groups (P > 0.05). After treatment, the levels of IL-8 in the two groups were higher than those before treatment, the levels of IFN-γ and CRP were lower than those before treatment, and the level of IL-8 in the observation group was higher than that in the control group, while the levels of IFN-γ and CRP were lower than those in the control group, the differences were statistically significant (P < 0.05). Before treatment, there was no significant difference in the level of immunoglobulin between the two groups (P > 0.05). After treatment, the levels of CD4+, IgA and IgM in the two groups were higher than those before treatment, and the levels of CD8^+ in the two groups were lower than those before treatment, and the levels of CD4^+, IgA and IgM in the observation group were higher than those in the control group, the level of CD8^+ in the observation group was lower than that in the control group, the differences were statistically significant (P < 0.05). The incidence of adverse reactions had no statistically significant difference between the two groups (P > 0.05). Conclusion Oseltamivir combined with Virus-Clearing Oral Liquid is effective in the treatment of influenza in children, which can significantly improve clinical symptoms and immunity, the complications are less, and it is worthy of clinical further promotion and application.