奥卡西平合用利培酮治疗癫痫性精神分裂症的效果

Effect of Oxcarbazepine combined with Risperidone in the treatment of epileptic schizophrenia

目的探讨奥卡西平合用利培酮治疗癫痫性精神分裂症的临床效果。方法选取2014年2月～2017年3月我院收治的89例癫痫性精神分裂症患者作为研究对象,使用随机数字表法将其分为对照组(44例)与观察组(45例)。对照组患者接受安慰剂联合利培酮治疗,观察组患者接受奥卡西平合用利培酮治疗。对所有患者进行至少1年的随访,比较两组患者的临床治疗效果、不同时间脑电图异常发生率和癫痫发作频率。结果接受治疗后12个月,观察组患者的治疗总有效率为95.56%,显著高于对照组的68.18%,差异有统计学意义(P<0.05)。两组患者治疗前的癫痫发作频率及脑电图异常发生率比较,差异无统计学意义(P>0.05);对照组患者治疗后6个月的脑电图异常发生率低于治疗前,治疗后12个月的癫痫发作频率及脑电图异常发生率均低于治疗前,差异有统计学意义(P<0.05);观察组患者治疗后6、12个月的癫痫发作频率及脑电图异常发生率均低于治疗前与对照组,差异有统计学意义(P<0.05)。结论在利培酮的基础上,联合奥卡西平治疗癫痫性精神分裂症患者,能够有效降低脑电图异常发生率和癫痫发作频率,提升临床效果,改善患者的预后,具有一定的价值。

Objective To explore the clinical effect of Oxcarbazepine combined with Risperidone in the treatment of epileptic schizophrenia.Methods A total of 89 cases of patients with epileptic schizophrenia admitted to our hospital from February 2014 to March 2017 were enrolled in the study,and they were divided into the control group(44 cases)and the observation group(45 cases)according to the random number table method.Patients in the control group received placebo combined with Risperidone,and patients in the observation group received Oxcarbazepine combined with Risperidone.All patients were followed up for at least 1 year.The clinical treatment effect,the incidence rate of electroencephalogram abnormalities and the frequency of epileptic seizures at different time were compared between the two groups.Results At 12 months after treatment,the total effective rate of treatment in the observation group was 95.56%,which was significantly higher than that in the control group(68.18%),and the difference was statistically significant(P<0.05).There were no significant differences in the frequency of epileptic seizures and the incidence rate of electroencephalogram abnormalities between the two groups before treatment(P>0.05).The incidence rate of electroencephalogram abnormalities in the control group at 6 months after treatment was lower than that before treatment,the frequency of epileptic seizures and the incidence rate of electroencephalogram abnormalities at 12 months after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The frequency of epileptic seizures and the incidence rate of electroencephalogram abnormalities at 6 and 12 months after treatment in the observation group were lower than those before treatment and in the control group,and the differences were statistically significant(P<0.05).Conclusion On the basis of Risperidone,the combination of Oxcarbazepine in the treatment of patients with epileptic schizophrenia can effectively reduce the incidence rate of electroencephalogram abnormalities and the frequency of epileptic seizures,increase clinical effect and improve prognosis of patients,with certain value.