阿莫西林、奥美拉唑联合克林霉素对Hp感染阳性胃溃疡患者血清炎性因子及TFF1、PG水平的影响研究

Study on effects of amoxicillin, omeprazole and clindamycin on serum inflammatory factor, TFF1 and PG levels in patients with Hp-positive gastric ulcer

目的研究阿莫西林、奥美拉唑联合克林霉素对幽门螺杆菌(Hp)感染阳性胃溃疡患者血清炎性因子[白细胞介素6(IL-6)、白细胞介素8(IL-8)和肿瘤坏死因子α(TNF-α)]及三叶因子1(TFF1)、血清胃蛋白酶原(PG)水平的影响。方法 132例Hp感染阳性胃溃疡患者,参考奇偶法分为观察组和对照组,各66例。观察组患者采用阿莫西林、奥美拉唑联合克林霉素三联疗法,对照组采用替硝唑、西咪替丁联合克林霉素三联疗法。观察和比较两组患者胃溃疡愈合效果、Hp根除情况、血清炎性因子和TFF1、PG水平。结果治疗后,观察组Hp根除率、痊愈率、总有效率分别为92.42%、51.52%、95.45%,均高于对照组的80.30%、33.33%、75.76%,差异有统计学意义(P<0.05)。观察组IL-6、IL-8和TNF-α水平分别为(159.00±8.46)、(0.238±0.03)、(30.18±4.12)pg/ml,均低于对照组的(290.00±12.40)、(0.430±0.06)、(57.10±6.38)pg/ml,差异有统计学意义(P<0.05)。观察组TFF1、PG水平分别为(2.01±0.60)ng/ml和(61.50±11.40)μg/L,均低于对照组的(4.97±1.64)ng/ml和(97.50±9.62)μg/L,差异有统计学意义(P<0.05)。结论阿莫西林、奥美拉唑联合克林霉素三联疗法能显著减轻Hp感染阳性胃溃疡患者炎症反应、根除Hp、促进胃黏膜修复,为临床治疗提供了参考依据。

Objective To study the effect of amoxicillin,omeprazole and clindamycin on serum inflammatory factor[interleukin-6(IL-6),interleukin-8(IL-8)and tumor necrosis factor-α(TNF-α)],trefoil factor 1(TFF1)and serum pepsinogen(PG)levels in patients with Helicobacter pylori(Hp)positive gastric ulcer.Methods A total of 132 patients with Helicobacter pylori(Hp)positive gastric ulcer were divided by even and odd number into observation group and control group,with 66 cases in each group.The observation group received amoxicillin,omeprazole and clindamycin triple therapy,and the control group received tinidazole,cimetidine and clindamycin triple therapy.Observation and comparison were made on healing effect of gastric ulcer,Hp eradication rate,serum inflammatory factors,TFF1 and PG levels between the two groups.Results After treatment,the observation group had higher Hp eradication rate,cure rate and total effective rate respectively as 92.42%,51.52%and 95.45%than 80.30%,33.33%and 75.76%in the control group,and the difference was statistically significant(P<0.05).The observation group had lower IL-6,IL-8 and TNF-αlevel respectively as(159.00±8.46),(0.238±0.03)and(30.18±4.12)pg/ml than(290.00±12.40),(0.430±0.06)and(57.10±6.38)pg/ml in the control group,and the difference was statistically significant(P<0.05).The observation group had lower TFF1 and PG level respectively as(2.01±0.60)ng/ml and(61.50±11.40)μg/L than(4.97±1.64)ng/ml and(97.50±9.62)μg/L in the control group,and the difference was statistically significant(P<0.05).Conclusion Triple therapy of amoxicillin,omeprazole and clindamycin can significantly reduce the inflammatory reaction,eradicate Hp and promote the repair of gastric mucosa in patients with gastric ulcer with HP-positive gastric ulcer.It provides a reference for clinical treatment.