支气管哮喘急性发作合并肺部感染患者IL-32、IgE水平与预后的相关性分析

Correlation analysis of IL-32,IgE level and prognosis in patients with acute attack of bronchial asthma complicated with pulmonary infection

目的探究支气管哮喘急性发作合并肺部感染患者白细胞介素-32(IL-32)、免疫球蛋白E(IgE)水平与预后的相关性。方法选取医院2015年5月-2016年5月收治的80例支气管哮喘患者作为研究对象,采用随机数表法将患者分为两组,其中40例支气管哮喘急性发作期患者为B组,40例支气管哮喘急性发作合并肺部感染患者为C组,并选取同期40名健康体检者作为A组。对B、C两组进行规范化治疗,比较B、C两组治疗效果,检测三组研究对象IL-32、IgE水平;对B、C两组患者随访,观察预后情况;并分析C组患者预后影响因素。结果随访结束时,B组患者缓解24例,有效率60%,C组患者缓解17例,有效率42.50%,B组患者治疗有效率高于C组(χ2=3.621,P=0.015);支气管哮喘患者IL-32、IgE水平高于健康人群(P<0.05);C组患者IL-32、IgE水平高于B组患者(P<0.05);B、C两组患者治疗后IL-32、IgE水平均低于治疗前(P<0.05);C组患者支气管哮喘急性发作次数、平均住院时间、平均住院次数高于B组,PEF值低于B组(P<0.05);Logistic回归分析显示,哮喘家族史、IL-32水平、IgE水平升高为影响支气管哮喘急性发作合并肺部感染预后的独立危险因素(P<0.05)。结论支气管哮喘急性发作合并肺部感染患者IL-32、IgE水平升高,并发现哮喘家族史、IL-32水平、IgE水平升高与支气管哮喘急性发作合并肺部感染预后密切相关。

OBJECTIVE To explore the correlation between the levels of IL-32 and IgE and the prognosis of patients with acute attack of bronchial asthma and pulmonary infection. METHODS 80 cases of bronchial asthma patients admitted in our hospital from May 2015 to May 2016 were enrolled, and randomly divided into two groups. Among them, group B included 40 cases of acute attack of bronchial asthma, group C included 40 patients with acute exacerbation of bronchial asthma complicated with pulmonary infection, and another 40 healthy persons with physical examination in the same period were selected as group A. The two groups of B and C received normalized treatment. The therapeutic effects of groups B and C were compared. The levels of IL-32 and IgE in the three groups were detected. The prognosis of groups B and C was followed up, and the influencing factors for the prognosis of group C were analyzed. RESULTS At the end of follow-up, 24 patients were relieved in group B, with an effective rate of 60%, and 17 patients were relieved in group C , with an effective rate of 42.50%. The effective rate of treatment in group B was significantly higher than that in group C (X^2 =3.621, P = 0.015). The IL-32 and IgE levels in bronchial asthma patients were significantly higher than those of healthy controls (P<0.05). The IL- 32 and IgE levels of patients in group C were significantly higher than those of group B (P<0.05). The IL-32 and IgE levels of patients in groups B and C after treatment were significantly lower than those before treatment (P< 0.05). In group C, the frequency of acute attack of bronchial asthma, the average time of hospitalization and the average number of hospitalization were higher than those of group B, and the value of PEF was significantly lower than that in group B (P<0.05). Logistic regression analysis showed that family history of asthma, increased IL- 32 level and IgE level were independent risk factors for the prognosis of acute attack of bronchial asthma combined with pulmonary infection (P<0.05).CONCLUSION The levels of IL-32 and IgE in patients with acute exacerbation of asthma and pulmonary infection increased significantly. It was found that the family history of asthma, increased IL-32 level and IgE level were closely related to the prognosis of patients with acute exacerbation of bronchial asthma combined with pulmonary infection.