摘要
通过检索PubMed、中国知网数据库和维普数据库关于达比加群酯不良反应的文献并对其进行回顾性分析和总结。达比加群酯致ADR的个案报道共73例;其性别分布男性44例(60.3%),女性29例(39.7%);年龄分布以70岁以上较多(59例,80.8%);多发生在用药后6个月内(60例,82.2%);达比加群酯致ADR临床表现以消化系统损害(50.7%)、血液系统损害(15.1%)和心血管系统损害(11.0%)多见。临床使用达比加群酯过程中应重点考量患者肾功能、年龄、体重和性别等危险因素,并重点监测和防治其ADR,避免ADR的发生。
PubMed,CNKI and VIP were searched for adverse drug reactions(ADRs)induced by dabigatran,the ADR cases domestically and internationally reported were analyzed statistically.A total of 73 ADR cases were identified as been induced by dabigatran,including 44 males(60.3%)and 29 females(39.7%).The patients were mainly over 70 years old(n=59,80.8%).The ADR occurred mostly(n=60,82.2%)within 6 months of medication and mainly in digestive system(50.7%),hematologic system(15.1%)and cardiovascular system(11.0%).So,during the use of dabigatran,the risk factors of renal function,age,weight and sex should be emphasized.Great importance should be attached to ADR monitoring to avoid serious ADR.
作者
崔姣
CUI Jiao(The Second Affiliated Hospital of Hunan University of Chinese Medicine,Changsha 410005)
出处
《药学与临床研究》
2019年第2期139-142,共4页
Pharmaceutical and Clinical Research
关键词
达比加群酯
不良反应
文献分析
Dabigatran
Adverse drug reactions
Literature analysis
