EB病毒致病机制研究进展

Research Progress in Pathogenesis of Epstein-Barr Virus

EB病毒(Epstein-Barr virus,EBV)是一种常见的人类4型疱疹病毒,原发感染后可终身携带病毒。EBV感染无法从宿主中清除,呈现潜伏状态,一旦激活即可成为很多疾病的相关病因,与人类多种疾病特别是恶性肿瘤相关,包括Burkitt淋巴瘤、鼻咽癌、胃癌等。EBV致病机制复杂多样,目前致病机制的具体分子遗传机制尚未明确。本文主要从EBV与宿主细胞相互作用、免疫逃逸、EBV感染周期表达的相关产物与宿主的相互作用等几个方面,综述目前EBV致病机制的研究进展。

Epstein ‐ Barr virus(EBV)is a common human type 4 herpes virus,which could be carried by the host for life after primary infection.The pathogenesis of EBV infection has never been cleared from the host, but stayed into the latent state.EBV is related to many kinds of diseases,once activated,EBV is related to human diseases,especially malignancies,including Burkitt lymphoma,nasopharyngeal cancer,and stomach cancer.EBV pathogenesis is so complicated that the specific molecular genetic mechanism of pathogenesis is difficult to determine.This article summarizes the research progress in the interaction between EBV and host cells, immune escape,and the interaction of the expression products of EBV in an infectious cycle with the host, which provids ideas and clues for further research.