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PTEN在器官纤维化疾病中的研究进展

Review of advances in the role of PTEN in fibrotic diseases
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摘要 纤维化是许多器官慢件疾病的终末期改变,其主要的病理特征为成纤维细胞的过度增殖、细胞外基质的大量沉积。至今其发病原因不甚明确,治疗效果也不理想。近年来研究发现,第十号染色体缺失的磷酸酶张力蛋白同源物基因(PTEN)与多种器官纤维化疾病的发生发展密切相关。本文就PTEN在重要器官纤维化发病中的作用及其分子机制研究进展作一综述。 Fibrosis is the endzage change of chronic diseases in many organs. whose main pathological features are excessive proliferation of fibroblasts and large deposition of extracellular matrix. So far. there is still no ideal therapeutic measures in fibrosis due to elusive pathogensis. In recent years, studies have shown lhal PTEN is closely correlated with the occurrence and developmenl of multiple organs fibrosis. This article reviews the role of PTEN in pathogensis of vital organs fibrosis and its related research in molecular mechanisms.
作者 谢丛意 谢宝松 XIE Cotigyi;XIE Baosong(De pa rt ment of Respiratory Medicine,Fujian Provincial Hospital. Fuzhou,Fujian 350001,China)
出处 《福建医药杂志》 CAS 2018年第A01期4-8,共5页 Fujian Medical Journal
基金 福建省财政厅资助项目(2100201).
关键词 纤维化 第十号染色体缺失的磷酸酶张力蛋白同源物皋因(PTEN) 机制 fibrosis phosphatase and ten si n homology deleted on chromosome ten mechanism
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