儿童结核病的诊断进展及耐药治疗的选择

Progress in diagnosis and selection of drug resistance therapy for childhood tuberculosis

儿童结核病的诊断具有挑战性,特别是在儿童中,传统和分子微生物学方法缺乏敏感性。随着科技进步,越来越多的检测方法被应用到临床中,从而可以及时的诊断结核,并在合适的时间予以治疗。当然结核病也是治疗最困难的传染病之一,是世界各地导致死亡的第二大传染病。其中多药耐药结核病和广泛耐药结核病正在增加,而它们的特点是病死率高,所以合适的药物选择在耐药结核病治疗中尤为关键。

Diagnosis of tuberculosis in children is challenging.Traditional and molecular microbiologic methods lack sensitivity, particularly in children.With the development of science and technology, more and more testing me-thods are applied in clinical practice, so that tuberculosis(TB) can be diagnosed in time and treated at the right time.TB is still one of the most difficult infectious diseases to treat, and the second most frequent cause of death due to infectious disease throughout the world.The number of cases of multidrug-resistant TB(MDR-TB) and extensively drug-resistant TB (XDR-TB), which are characterized by high mortality rates, is increasing.Therefore, appropriate drug selection is particularly critical in the treatment of drug-resistant tuberculosis.