3-((4-丙基-5-(嘧啶-4-基)-4H-1,2,4-三唑-3-基)甲胺基)-N-(2,6-二氟苯基)苯甲酰胺的合成及结构表征

Synthesis and Structure Characterization of 3-((4-propyl-5-(pyrimidin-4-yl)-4H-1,2,4-triazol-3-yl) methylamino)-N-(2,6-difluorobenzyl) Benzamide

以3-氨基苯甲酸甲酯为原料,经氨基的亲核取代、肼解、环合、亲核加成等一系列反应合成3-((4-丙基-5-(嘧啶-4-基)-4H-1,2,4-三唑-3-基)甲胺基)-N-(2,6-二氟苯基)苯甲酰胺。借助1H NMR和LC-MS等方法对所合成的中间体和目标产物的结构进行了表征。

3-((4-propyl-5-(pyrimidin-4-yl)-4H-1,2,4-triazol-3-yl)methylamino)-N-(2,6-difluorobenzyl)benzamide was synthesized from methyl 3-aminobenzoate by nucleophilic substitution,hydrazinolysis,cyclization,and nucleophilic addition to yield the target product.The structures of the target compound and its intermediates were characterized by 1 H NMR and LC-MS.