摘要
白藜芦醇三甲醚经Vilsmeier-Haack反应生成中间产物B,收率为93%。中间体B再和4-甲基-2-羟基苯乙酮经Cross Aldol反应,得到白藜芦醇查尔酮类衍生物,收率为84%。终产物利用溶剂缓慢挥发法得到单晶并对其结构分析。该方法具有合成步骤简单,成本低,产率高等优点。
Resveratrol trimethyl ether was reacted with Vilsmeier-Haack to form intermediate B in a yield of 93%. Intermediate B was further reacted with 4-methyl-2-hydroxyacetophenone by Cross Aldol to give a resveratrol chalco ne derivative end product in a yield of 84 %. The final product was subjected to a slow solvent evaporation method to obtain a single crystal and its structure was analyzed. The method has the advantages of simple synthesis steps, low cost and high yield.
作者
张丽娜
李遥
阮班锋
周本国
ZHANG Li-na;LI Yao;RUAN Ban-feng;ZHOU Ben-gao(Anhui Provincinal Corporation of China National Tobacoo Corporation, Hefei 230002,China;Institute of Tobacoo Research, Anhui Academy of Agricultural Sciences, Hefei 230031,China;School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009,China)
出处
《安徽化工》
CAS
2019年第2期50-53,共4页
Anhui Chemical Industry
关键词
白藜芦醇
查尔酮衍生物
合成
单晶结构
resveratrol
chalcone derivative
synthesis
single crystal structure