小剂量左甲状腺素治疗良性甲状腺结节的临床效果

Clinical effect of small dose levothyroxine in the treatment of benign thyroid nodules

目的探究小剂量左甲状腺素治疗良性甲状腺结节的临床效果。方法选取2017年11月至2018年10月我院收治的29例良性甲状腺结节患者作为研究对象,给予小剂量左甲状腺素治疗,分析患者治疗效果及不良反应发生情况。结果治疗后,患者的游离三碘甲状腺原氨酸(FT3)、游离甲状腺素(FT4)、促甲状腺激素(TSH)水平以及甲状腺结节体积均显著优于治疗前,差异具有统计学意义(P<0.05);治疗后,有2例出现心悸(6.90%),1例出现胸闷(3.45%),1例出现震颤(3.45%),不良反应总发生率为13.79%。结论小剂量左甲状腺素治疗良性甲状腺结节患者,可有效改善患者的FT3、FT4以及TSH水平,缩减甲状腺结节体积,安全性较高,值得临床推广应用。

Objective To investigate the clinical effect of small dose levothyroxine in the treatment of benign thyroid nodules. Methods Twenty-nine patients with benign thyroid nodules admitted in our hospital from November 2017 to October 2018 were selected as research objects. All patients were treated with small dose levothyroxine. The clinical treatment effects and adverse reactions were analyzed. Results After treatment, the levels of free triiodothyronine(FT3), free thyroxine(FT4), thyroid stimulating hormone(TSH) and thyroid nodule volume of patients were significantly better than those before treatment(P<0.05);after treatment, palpitation occurred in 2 cases(6.90%), chest tightness in 1 case(3.45%)and tremor in 1 case(3.45%), the total incidence of adverse reactions was 13.79%. Conclusion Small dose levothyroxine can effectively improve the levels of FT4, FT3 and TSH of patients with benign thyroid nodules, reduce the volume of thyroid nodules, with higher safety, which is worthy of clinical promotion and application.