溃疡性结肠炎频发的危险因素Logistic回归分析

Logistic regression analysis of risk factors for frequent incidence of ulcerative colitis

目的分析影响溃疡性结肠炎(UC)频发的危险因素。方法收集2015年1月至2018年6月在我院确诊并住院治疗的慢性复发型UC患者119例的临床资料,根据复发次数将112例(除去7例为持续型)UC患者分为频发组(n=61)与偶发组(n=51)。采用单因素及多因素Logistic回归分析对影响UC频发的因素进行分析。结果单因素分析结果显示,两组患者的用药依从性、SAS评分、SDS评分、疾病严重程度、内镜下评分比较,差异有统计学意义(P<0.05);多因素Logistic回归分析结果显示,用药依从性、SAS评分、SDS评分、重度病情及内镜下评分是影响慢性复发型UC频发的独立危险因素(P<0.05)。结论 UC患者频发与多种因素相关,临床应加强依从性管理,改善患者心理状况,延缓疾病进展,尽可能达到内镜下黏膜愈合标准以减少复发次数,提高患者生存质量。

Objective To analyze the risk factors affecting the frequency of ulcerative colitis(UC). Methods The clinical data of 119 patients with chronic recurrent UC diagnosed and hospitalized in our hospital from January 2015 to June 2018 were collected. A total of 112 patients(excluding 7 patients with persistent UC) were divided into frequent group(n=61)and accidental group(n =51) according to the numbers of recurrence. Univariate and multivariate Logistic regression analysis were used to analyze the risk factors affecting the frequency of UC. Results The results of univariate analysis showed that there were significant differences in medication compliance, SAS scores, SDS scores, disease severity and endoscopy scores between the two groups(P <0.05). The results of multivariate Logistic regression analysis showed that medication compliance, SAS scores, SDS scores, severe disease and endoscopy score were the independent risk factors affecting the frequent incidence of chronic recurrent UC(P<0.05). Conclusion The frequent incidence of UC is related to many factors. It is necessary to strengthen the management of drug compliance of patients, improve the psychological status of patients, delay the progress of the disease and reach the criteria of endoscopic mucosal healing as far as possible, so as to reduce the numbers of recurrence and improve the quality of life of patients.