麻杏石甘汤加味治疗外寒内热证慢阻肺急性加重期的临床效果

Clinical effect of modified Maxing Shigan decoction on acute exacerbation of chronic obstructive pulmonary disease with external cold and internal heat syndrome

目的探讨麻杏石甘汤加味治疗外寒内热证慢阻肺急性加重期的临床效果。方法将我院收治的60例外寒内热证慢阻肺急性加重期患者采用随机数表法分为对照组(常规西医)和研究组(加用麻杏石甘汤加味),各30例。比较两组治疗效果。结果研究组咳嗽、咯痰、喘息气短及干啰音症状显控率高于对照组(P<0.05)。研究组治疗显控率高于对照组(P<0.05)。治疗后,研究组FVC、FEV_1及FEV_1%均升高(P<0.05)。治疗后,两组LTB4、IL-8、TNF-α水平均降低,且研究组均低于对照组(P<0.05)。两组均无明显不良反应发生。结论麻杏石甘汤加减治疗外寒内热慢阻肺急性加重期效果显著,且可有效改善患者临床症状及肺功能,减少机体炎症反应,且安全性高。

Objective To explore the clinical effect of modified Maxing Shigan decoction on acute exacerbation of chronic obstructive pulmonary disease with external cold and internal heat syndrome. Methods Sixty patients with acute exacerbation of chronic obstructive pulmonary disease with external cold and internal heat syndrome treated in our hospital were divided into control group (routine western medicine) and study group (added to modified Maxing Shigan decoction) by random number table method, with 30 cases in each group. The therapeutic effects of both groups were compared. Results The efficiency and control rate of cough, expectoration, shortness of breath and dry rale symptoms in the study group were significantly higher than those in the control group (P<0.05). The efficiency and control rate of treatment in the study group was higher than that in the control group (P<0.05). After treatment, the levels of FVC, FEV1 and FEV1% in the study group increased (P<0.05). After treatment, the levels of LTB4, IL-8 and TNF-α in both groups decreased, and those in the study group were lower than the control group (P<0.05). There were no obvious adverse reactions in both groups. Conclusion Modified Maxing Shigan decoction is effective in the treatment of acute exacerbation of chronic obstructive pulmonary disease with external cold and internal heat syndrome. It can effectively improve the clinical symptoms and pulmonary function of patients, reduce inflammation reactions and has high safety.