T淋巴细胞在动脉粥样硬化中的研究进展被引量：2

Research progress of T lymphocyte in atherosclerosis

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摘要除了单核/巨噬细胞有重要的致动脉粥样硬化(AS)作用外,T细胞在AS中也起着重要作用。辅助性T细胞1型(Th1)通过强烈的致凋亡作用影响AS,其他T细胞亚群如Th2和Th17也参与AS的发生发展。调节性T细胞(Tregs)还与Th2相关细胞因子相互作用抑制AS发展。然而现在对T细胞在AS中的具体作用机制尚不明确。本文就T细胞在AS中的作用及这些细胞可能为AS研究和治疗提供的方向作一综述。 T cells play an important role in atherosclerosis (AS) besides monocytes and macrophages. The T helper cell type 1 (Th1) affect AS via strong apoptotic effect, other T cell subgroups are also involved in occurrence and development of AS, such as Th2 and Th17. The interaction between regulatory T cells (Tregs) and Th2 related cytokines can inhibit AS development. However, mechanism of T cells in AS is still not clear. The present article made a review on role of T cells in AS and their possible guidance for research and treatment of AS.

作者张胜男王美琪吴健于波孙勇 ZHANG Sheng-nan;WANG Mei-qi;WU Jian;YU Bo;SUN Yong(Department of Cardiology, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150001, China)

机构地区哈尔滨医科大学附属第二医院心内科

出处《心血管康复医学杂志》 CAS 2019年第2期241-244,共4页 Chinese Journal of Cardiovascular Rehabilitation Medicine

基金国家自然科学基金(81771946 81670373)~~

关键词动脉粥样硬化 T淋巴细胞 T淋巴细胞亚群 Atherosclerosis T-Lymphocytes T-Lymphocyte subsets

分类号 R543.509 [医药卫生—心血管疾病]

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1Yang ZHAO,Xiao-yan DAI,Zhou ZHOU,Ge-xin ZHAO,Xian WANG,Ming-jiang XU.Leucine supplementation via drinking water reduces atherosclerotic lesions in apoE null mice[J].Acta Pharmacologica Sinica,2016,37(2):196-203. 被引量：7
2田雨灵,王丽君,吴岳,张卫萍,梁潇,袁祖贻.吡格列酮通过调控TGF-β信号通路和T细胞调节性免疫机制缓解ApoE^(-/-)小鼠动脉粥样硬化（英文）[J].南方医科大学学报,2017,37(8):1003-1009. 被引量：5

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